creators_name: Sharma, Yogesh 
creators_name: Pawar, Ganesh P.
creators_name: Chaudhari, Vinod
type: article
datestamp: 2024-07-15 04:03:24
lastmod: 2024-07-15 04:03:24
metadata_visibility: show
title: One-Pot Domino Reaction: Direct Access to Polysubstituted 1,4-Benzothiazine 1,1-Dioxide via Water-Gas Shift Reaction Utilizing DMF/H2O
ispublished: pub
subjects: QR
note: The copyright of this article belongs to ACS Publications 
abstract: Benzothiazine 1,1-dioxide (BTDO) is a privileged chemical motif, and its metal-free domino access is in high demand. Current BTDO production methods require costly metal catalysts or harsh reaction conditions. A facile domino approach to BTDO via a water-gas shift reaction (WGSR) employing sodium 2-nitrobenzenesulfinates and α-bromo ketones is presented. This strategy is cost-effective and environmentally beneficial. The optimized reaction conditions demonstrated remarkable chemical tolerance to a wide range of electrically and sterically varied substituents on both coupling partners.


date: 2022-12
date_type: published
publication: Journal of Organic Chemistry
volume: 88
number: 1
publisher: ACS Publications 
pagerange: 701-710
id_number: 10.1021/acs.joc.2c02171
refereed: TRUE
official_url: https://pubs.acs.org/doi/10.1021/acs.joc.2c02171
citation:   Sharma, Yogesh  and Pawar, Ganesh P. and Chaudhari, Vinod  (2022) One-Pot Domino Reaction: Direct Access to Polysubstituted 1,4-Benzothiazine 1,1-Dioxide via Water-Gas Shift Reaction Utilizing DMF/H2O.  Journal of Organic Chemistry, 88 (1).  pp. 701-710.