creators_name: Yadav, Jyoti
creators_name: Das, Satyajeet
creators_name: Karthikeyan, Divyapriya
creators_name: Chugh, Ravneet
creators_name: Jyoti, Anupam 
creators_name: Srivastava, Vijay Kumar
creators_name: Jain, Ajay
creators_name: Kumar, Sanjit
creators_name: Sharma, Vinay
creators_name: Kaushik, Sanket
type: article
datestamp: 2024-07-15 04:17:41
lastmod: 2024-07-15 04:17:41
metadata_visibility: show
title: Identification of Protein Drug Targets of Biofilm Formation and Quorum Sensing in Multidrug Resistant Enterococcus faecalis. 
ispublished: pub
subjects: QR
keywords: MDR; Multidrug resistant bacteria; QS; biofilm; quorum sensing; rational structure based drug design.
note: The copyright of this article belongs to BENTHAM SCIENCE 
abstract: Enterococcus faecalis (E. faecalis) is an opportunistic multidrug-resistant (MDR) pathogen found in the guts of humans and farmed animals. Due to the occurrence of (MDR) strain there is an urgent need to look for an alternative treatment approach. E. faecalis is a Gram-positive bacterium, which is among the most prevalent multidrug resistant hospital pathogens. Its ability to develop quorum sensing (QS) mediated biofilm formation further exacerbates the pathogenicity and triggers lifethreatening infections. Therefore, developing a suitable remedy for curing E. faecalis mediated enterococcal infections is an arduous task. Several putative virulence factors and proteins are involved in the development of biofilms in E. faecalis. Such proteins often play important roles in virulence, disease, and colonization by pathogens. The elucidation of the structure-function relationship of such protein drug targets and the interacting compounds could provide an attractive paradigm towards developing structure-based drugs against E. faecalis. This review provides a comprehensive overview of the current status, enigmas that warrant further studies, and the prospects toward alleviating the antibiotic resistance in E. faecalis. Specifically, the role of biofilm and quorum sensing (QS) in the emergence of MDR strains had been elaborated along with the importance of the protein drug targets involved in both the processes.


date: 2022-07-22
date_type: published
publication: Current Protein and Peptide Science 
volume: 23
number: 4
publisher: BENTHAM SCIENCE 
pagerange: 248-263
id_number: 10.2174/1389203723666220526155644
refereed: TRUE
official_url: https://www.eurekaselect.com/article/123998
citation:   Yadav, Jyoti and Das, Satyajeet and Karthikeyan, Divyapriya and Chugh, Ravneet and Jyoti, Anupam  and Srivastava, Vijay Kumar and Jain, Ajay and Kumar, Sanjit and Sharma, Vinay and Kaushik, Sanket  (2022) Identification of Protein Drug Targets of Biofilm Formation and Quorum Sensing in Multidrug Resistant Enterococcus faecalis.  Current Protein and Peptide Science , 23 (4).  pp. 248-263.