@prefix epid: <http://crdd.osdd.net/open/id/> .
  @prefix dc: <http://purl.org/dc/elements/1.1/> .
  @prefix geo: <http://www.w3.org/2003/01/geo/wgs84_pos#> .
  @prefix bibo: <http://purl.org/ontology/bibo/> .
  @prefix owl: <http://www.w3.org/2002/07/owl#> .
  @prefix void: <http://rdfs.org/ns/void#> .
  @prefix event: <http://purl.org/NET/c4dm/event.owl#> .
  @prefix skos: <http://www.w3.org/2004/02/skos/core#> .
  @prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
  @prefix cc: <http://creativecommons.org/ns#> .
  @prefix ep: <http://eprints.org/ontology/> .
  @prefix foaf: <http://xmlns.com/foaf/0.1/> .
  @prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
  @prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
  @prefix eprel: <http://eprints.org/relation/> .
  @prefix dct: <http://purl.org/dc/terms/> .

<>
	foaf:primaryTopic <http://crdd.osdd.net/open/id/eprint/3167>;
	rdfs:comment "The repository administrator has not yet configured an RDF license."^^xsd:string .

<http://crdd.osdd.net/open/3167/>
	dc:format "text/html";
	dc:title "HTML Summary of #3167 \n\nEfflux pump inhibitory potential of indole derivatives as an arsenal against norA over-expressing Staphylococcus aureus\n\n";
	foaf:primaryTopic <http://crdd.osdd.net/open/id/eprint/3167> .

<http://crdd.osdd.net/open/id/eprint/3167#authors>
	rdf:_1 <http://crdd.osdd.net/open/id/person/ext-9678792ad922e5f2a00341aca16696a8>;
	rdf:_2 <http://crdd.osdd.net/open/id/person/ext-3f9d027c066d8e45fc66228f5db2cbcf>;
	rdf:_3 <http://crdd.osdd.net/open/id/person/ext-de0e45745aab07b8ca355f50d20f3d46>;
	rdf:_4 <http://crdd.osdd.net/open/id/person/ext-534f8853597d104167a37d46463f52a7>;
	rdf:_5 <http://crdd.osdd.net/open/id/person/ext-2d3ee6a9ba3a7960d43b51dce7b59e5a>;
	rdf:_6 <http://crdd.osdd.net/open/id/person/ext-543a9722765a2ba5ad80691e66579bd0>;
	rdf:_7 <http://crdd.osdd.net/open/id/person/ext-88d08a092f12ff34c45b999a20c37b97> .

<http://crdd.osdd.net/open/id/eprint/3167>
	bibo:abstract "NorA, an extensively studied efflux pump in Staphylococcus aureus, has been connected to fluoroquinolone, antiseptic, and disinfection resistance. Several studies have also emphasized how efflux pumps, including NorA, function as the first line of defense of S. aureus against antibiotics. In this study, we have screened some chemically synthesized indole derivatives for their activity as efflux pump inhibitors (EPIs). The derivative SMJ-5 was found to be a potent NorA efflux pump inhibitor among the screened indole derivatives, owing to increased ethidium bromide and norfloxacin accumulation in norA over-expressing S. aureus. The combination of SMJ-5 and ciprofloxacin demonstrated the eradication of S. aureus biofilm and prolonged the post-antibiotic effect more than ciprofloxacin alone. SMJ-5 was able to inhibit staphyloxanthin virulence. In in vitro time-kill trials and in vivo efficacy investigations, the combination enhanced the bactericidal activity of ciprofloxacin against S. aureus. Additionally, reverse transcription PCR results revealed that SMJ-5 also inhibits the NorA efflux pump indirectly at the transcriptional level.\r\n"^^xsd:string;
	bibo:authorList <http://crdd.osdd.net/open/id/eprint/3167#authors>;
	bibo:issue "5";
	bibo:status <http://purl.org/ontology/bibo/status/peerReviewed>,
		<http://purl.org/ontology/bibo/status/published>;
	bibo:volume "11";
	dct:creator <http://crdd.osdd.net/open/id/person/ext-2d3ee6a9ba3a7960d43b51dce7b59e5a>,
		<http://crdd.osdd.net/open/id/person/ext-3f9d027c066d8e45fc66228f5db2cbcf>,
		<http://crdd.osdd.net/open/id/person/ext-88d08a092f12ff34c45b999a20c37b97>,
		<http://crdd.osdd.net/open/id/person/ext-534f8853597d104167a37d46463f52a7>,
		<http://crdd.osdd.net/open/id/person/ext-543a9722765a2ba5ad80691e66579bd0>,
		<http://crdd.osdd.net/open/id/person/ext-9678792ad922e5f2a00341aca16696a8>,
		<http://crdd.osdd.net/open/id/person/ext-de0e45745aab07b8ca355f50d20f3d46>;
	dct:date "2023-09-27";
	dct:isPartOf <http://crdd.osdd.net/open/id/repository>,
		<http://crdd.osdd.net/open/id/publication/ext-35b6cf19b8a5a8204aebf6283ff418a3>;
	dct:publisher <http://crdd.osdd.net/open/id/org/ext-724015dbaa73c7fd1fece78db4264bf2>;
	dct:subject <http://crdd.osdd.net/open/id/subject/QR>;
	dct:title "Efflux pump inhibitory potential of indole derivatives as an arsenal against norA over-expressing Staphylococcus aureus"^^xsd:string;
	rdf:type bibo:AcademicArticle,
		bibo:Article,
		ep:ArticleEPrint,
		ep:EPrint;
	rdfs:seeAlso <http://crdd.osdd.net/open/3167/> .

<http://crdd.osdd.net/open/id/subject/QR>
	rdf:type skos:Concept;
	skos:prefLabel "QR Microbiology"@en .

<http://crdd.osdd.net/open/id/org/ext-724015dbaa73c7fd1fece78db4264bf2>
	foaf:name "ASM"^^xsd:string;
	rdf:type foaf:Organization .

<http://crdd.osdd.net/open/id/person/ext-2d3ee6a9ba3a7960d43b51dce7b59e5a>
	foaf:familyName "Mahey"^^xsd:string;
	foaf:givenName "Nisha"^^xsd:string;
	foaf:name "Nisha Mahey"^^xsd:string;
	rdf:type foaf:Person .

<http://crdd.osdd.net/open/id/person/ext-3f9d027c066d8e45fc66228f5db2cbcf>
	foaf:familyName "Tambat"^^xsd:string;
	foaf:givenName "Rushikesh"^^xsd:string;
	foaf:name "Rushikesh Tambat"^^xsd:string;
	rdf:type foaf:Person .

<http://crdd.osdd.net/open/id/person/ext-88d08a092f12ff34c45b999a20c37b97>
	foaf:familyName "Nandanwar"^^xsd:string;
	foaf:givenName "Hemraj"^^xsd:string;
	foaf:name "Hemraj Nandanwar"^^xsd:string;
	rdf:type foaf:Person .

<http://crdd.osdd.net/open/id/person/ext-534f8853597d104167a37d46463f52a7>
	foaf:familyName "Kumar"^^xsd:string;
	foaf:givenName "Gautam"^^xsd:string;
	foaf:name "Gautam Kumar"^^xsd:string;
	rdf:type foaf:Person .

<http://crdd.osdd.net/open/id/person/ext-543a9722765a2ba5ad80691e66579bd0>
	foaf:familyName "Jachak "^^xsd:string;
	foaf:givenName "Sanjay"^^xsd:string;
	foaf:name "Sanjay Jachak "^^xsd:string;
	rdf:type foaf:Person .

<http://crdd.osdd.net/open/id/person/ext-9678792ad922e5f2a00341aca16696a8>
	foaf:familyName "Chandal"^^xsd:string;
	foaf:givenName "Nishtha"^^xsd:string;
	foaf:name "Nishtha Chandal"^^xsd:string;
	rdf:type foaf:Person .

<http://crdd.osdd.net/open/id/person/ext-de0e45745aab07b8ca355f50d20f3d46>
	foaf:familyName "Kalia"^^xsd:string;
	foaf:givenName "Ritu"^^xsd:string;
	foaf:name "Ritu Kalia"^^xsd:string;
	rdf:type foaf:Person .

<http://crdd.osdd.net/open/id/publication/ext-35b6cf19b8a5a8204aebf6283ff418a3>
	foaf:name "Microbiology Spectrum  "^^xsd:string;
	rdf:type bibo:Collection .