…
comment: The repository administrator has not yet configured an RDF license.
primary topic: Emerging aspects of cytokine storm in COVID-19: The role of proinflammatory cytokines and therapeutic prospects

Emerging aspects of cytokine storm in COVID-19: The role of proinflammatory cytokines and therapeutic prospects
type: AcademicArticle
type: Article
abstract: COVID-19 has claimed millions of lives during the last 3 years since initial cases were reported in Wuhan, China, in 2019. Patients with COVID-19 suffer from severe pneumonia, high fever, acute respiratory distress syndrome (ARDS), and multiple-organ dysfunction, which may also result in fatality in extreme cases. Cytokine storm (CS) is hyperactivation of the immune system, wherein the dysregulated production of proinflammatory cytokines could result in excessive immune cell infiltrations in the pulmonary tissues, resulting in tissue damage. The immune cell infiltration could also occur in other tissues and organs and result in multiple organs' dysfunction. The key cytokines implicated in the onset of disease severity include TNF-α, IFN-γ, IL-6, IL-1β, GM-CSF, and G-CSF. Controlling the CS is critical in treating COVID-19 disease. Therefore, different strategies are employed to mitigate the effects of CS. These include using monoclonal antibodies directed against soluble cytokines or the cytokine receptors, combination therapies, mesenchymal stem cell therapy, therapeutic plasma exchange, and some non-conventional treatment methods to improve patient immunity. The current review describes the role/s of critical cytokines in COVID-19-mediated CS and the respective treatment modalities.
date: 2023-09
volume: 169
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
subject: QR Microbiology

Elsevier Science
type: Organization

Cytokine
type: Collection

Sonal Datta
type: Person
given name: Sonal
family name: Datta

Renu Dharra
type: Person
given name: Renu
family name: Dharra

Anil Kumar Sharma
type: Person
given name: Anil Kumar
family name: Sharma

HTML Summary of #3175 Emerging aspects of cytokine storm in COVID-19: The role of proinflammatory cytokines and therapeutic prospects
format: text/html
primary topic: Emerging aspects of cytokine storm in COVID-19: The role of proinflammatory cytokines and therapeutic prospects

QR Microbiology
type: Concept