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primary topic: ProGlycProt V3.0: updated insights into prokaryotic glycoproteins and their glycosyltransferases

ProGlycProt V3.0: updated insights into prokaryotic glycoproteins and their glycosyltransferases
type: AcademicArticle
type: Article
abstract: ProGlycProt is a comprehensive database of experimentally validated information about protein glycosylation in prokaryotes, including the glycoproteins, glycosyltransferases, and their accessory enzymes. The first release of ProGlycProt featured experimentally validated information on glycoproteins only. For the second release in 2019, the size and scope of the database were expanded twofold, and experimental data on cognate glycosyltransferases and their accessory proteins was incorporated. The growing research and technology interest in microbial glycoproteins and their enzymes is evident from the steady rise in academic publications and patents in this area. Accordingly, the third update comprises a new section on patents related to glycosylation methods, novel glycosyltransferases, and technologies developed therefrom. The structure gallery is reorganized, wherein the number and quality of the models are upgraded with the help of AlphaFold2. Over the years, the influx of experimental proteomics data into public repositories like PRIDE has surged. Harnessing this legacy data for in-silico glycoprotein identification is a smart approach. Version 3.0 adds 45 N-glycoprotein entries annotated from MS datasets available on PRIDE and reviewed by independent research groups. With a 67% rise in entries corresponding to 119 genera of prokaryotes, the ProGlycProt continues to be the exclusive database of experimentally validated comprehensive information about protein glycosylation in prokaryotes.
date: 2023-04-01
volume: 34
issue: 3
is part of: Glycobiology
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
subject: QR Microbiology

Oxford University Press
type: Organization

Glycobiology
type: Collection
issn: 14602423

Alka Rao
type: Person
given name: Alka
family name: Rao

Shreya Janhvi
type: Person
given name: Shreya
family name: Janhvi

Tarun Kumar Sharma
type: Person
given name: Tarun Kumar
family name: Sharma

Vaidhvi Singh
type: Person
given name: Vaidhvi
family name: Singh

Sikha Saini
type: Person
given name: Sikha
family name: Saini

HTML Summary of #3178 ProGlycProt V3.0: updated insights into prokaryotic glycoproteins and their glycosyltransferases
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primary topic: ProGlycProt V3.0: updated insights into prokaryotic glycoproteins and their glycosyltransferases

QR Microbiology
type: Concept