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primary topic: Nanoscale size impact of nanoparticle interaction and activity studies with urease

Nanoscale size impact of nanoparticle interaction and activity studies with urease
type: AcademicArticle
type: Article
abstract: Herein, we provide insights into the size-dependent interactions of silver nanoparticles (AgNPs) with urease and their implications for enzyme inhibition. AgNPs with a size of 5 nm exhibited the strongest binding affinity of 66 nM, resulting in significant enzyme attachment, interfering enzyme conformation, and a consequent loss of activity. Mid-sized AgNPs, i.e., 20 and 50 nm, exhibited binding affinities of 712 and 616 nM, causing only slight structural alterations. In contrast, 100 nm AgNPs demonstrated a high binding affinity of 171 nM accompanied by a favorable enthalpic contribution and a pronounced inhibitory effect.
date: 2025
volume: 17
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository

The Royal Society of Chemistry
type: Organization

Nanoscale
type: Collection

Priya Bhardwaj
type: Person
given name: Priya
family name: Bhardwaj

Bhawana Bisht
type: Person
given name: Bhawana
family name: Bisht

Vijayender Bhalla
type: Person
given name: Vijayender
family name: Bhalla

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primary topic: Nanoscale size impact of nanoparticle interaction and activity studies with urease