@article{open3210, volume = {61}, title = {A dual-function probe for inhibition and rapid detection of Mycobacterium tuberculosis}, author = {Sonali Chhabra and Raman Parkesh}, publisher = {The Royal Society of Chemistry}, year = {2025}, pages = {12123--12126}, journal = {Chem. Commun.}, url = {http://crdd.osdd.net/open/3210/}, abstract = {We introduce a dual-purpose solvatochromic naphthalimide-benzothiazinone (BTZ) conjugate with theranostic potential that enables specific and rapid detection of Mycobacterium tuberculosis by targeting the DprE1 enzyme, while also exhibiting antimicrobial activity. The photoinduced electron transfer (PeT)-based fluorophore incorporates into the mycobacterial cell wall, producing detectable fluorescence within 15 minutes and thus, highlighting its suitability for rapid, point-of-care TB detection in low-resource settings.} }