%0 Journal Article
%A Chhabra, Sonali
%A Parkesh, Raman
%D 2025
%F open:3210
%I The Royal Society of Chemistry
%J Chem. Commun.
%P 12123-12126
%T A dual-function probe for inhibition and rapid detection of Mycobacterium tuberculosis
%U http://crdd.osdd.net/open/3210/
%V 61
%X We introduce a dual-purpose solvatochromic naphthalimide-benzothiazinone (BTZ) conjugate with theranostic potential that enables specific and rapid detection of Mycobacterium tuberculosis by targeting the DprE1 enzyme, while also exhibiting antimicrobial activity. The photoinduced electron transfer (PeT)-based fluorophore incorporates into the mycobacterial cell wall, producing detectable fluorescence within 15 minutes and thus, highlighting its suitability for rapid, point-of-care TB detection in low-resource settings.