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primary topic: A dual-function probe for inhibition and rapid detection of Mycobacterium tuberculosis

A dual-function probe for inhibition and rapid detection of Mycobacterium tuberculosis
type: AcademicArticle
type: Article
abstract: We introduce a dual-purpose solvatochromic naphthalimide-benzothiazinone (BTZ) conjugate with theranostic potential that enables specific and rapid detection of Mycobacterium tuberculosis by targeting the DprE1 enzyme, while also exhibiting antimicrobial activity. The photoinduced electron transfer (PeT)-based fluorophore incorporates into the mycobacterial cell wall, producing detectable fluorescence within 15 minutes and thus, highlighting its suitability for rapid, point-of-care TB detection in low-resource settings.
date: 2025
volume: 61
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository

The Royal Society of Chemistry
type: Organization

Chem. Commun.
type: Collection

Raman Parkesh
type: Person
given name: Raman
family name: Parkesh

Sonali Chhabra
type: Person
given name: Sonali
family name: Chhabra

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primary topic: A dual-function probe for inhibition and rapid detection of Mycobacterium tuberculosis