creators_name: Chhabra, Sonali
creators_name: Parkesh, Raman
type: article
datestamp: 2026-02-02 07:23:34
lastmod: 2026-02-02 07:23:34
metadata_visibility: show
title: A dual-function probe for inhibition and rapid detection of Mycobacterium tuberculosis
abstract: We introduce a dual-purpose solvatochromic naphthalimide-benzothiazinone (BTZ) conjugate with theranostic potential that enables specific and rapid detection of Mycobacterium tuberculosis by targeting the DprE1 enzyme, while also exhibiting antimicrobial activity. The photoinduced electron transfer (PeT)-based fluorophore incorporates into the mycobacterial cell wall, producing detectable fluorescence within 15 minutes and thus, highlighting its suitability for rapid, point-of-care TB detection in low-resource settings.
date: 2025
publication: Chem. Commun.
volume: 61
publisher: The Royal Society of Chemistry
pagerange: 12123-12126
official_url: http://dx.doi.org/10.1039/D5CC02317C
citation:   Chhabra, Sonali and Parkesh, Raman  (2025) A dual-function probe for inhibition and rapid detection of Mycobacterium tuberculosis.  Chem. Commun., 61.  pp. 12123-12126.