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primary topic: Tubules, rods, and spirals: Diverse modes of SepF-FtsZ assembling

Tubules, rods, and spirals: Diverse modes of SepF-FtsZ assembling
type: AcademicArticle
type: Article
abstract: Z-ring formation by FtsZ, the master assembler of the divisome, is a key step in bacterial cell division. Membrane anchoring of the Z-ring requires the assistance of dedicated Z-ring binding proteins, such as SepF and FtsA. SepF participates in bundling and membrane anchoring of FtsZ in gram-positive bacteria. We report in vitro biophysical studies of the interactions between FtsZ and a cytoplasmic component of cognate SepF from three different bacteria: Mycobacterium tuberculosis, Staphylococcus aureus, and Enterococcus gallinarum. While the cytosolic domain of SepF from M. tuberculosis is primarily a dimer, those from S. aureus and E. gallinarum polymerize to form ring-like structures. Mycobacterial SepF helps in the bundling of FtsZ filaments to form thick filaments and large spirals. On the other hand, ring-forming SepF from the Firmicutes bundle FtsZ into tubules. Our results suggest that the oligomeric form of SepF directs how it bundles FtsZ filaments.
date: 2025-07
volume: 82
issue: 7
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository

Wiley
type: Organization

Cytoskeleton (Hoboken)
type: Collection

Jagrity Choudhury
type: Person
given name: Jagrity
family name: Choudhury

Barnali N Chaudhuri
type: Person
given name: Barnali N
family name: Chaudhuri

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primary topic: Tubules, rods, and spirals: Diverse modes of SepF-FtsZ assembling