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primary topic: Genomic insights into novel predatory myxobacteria isolated from human feces

Genomic insights into novel predatory myxobacteria isolated from human feces
type: AcademicArticle
type: Article
abstract: Myxobacteria are Gram-negative, spore-forming predatory bacteria isolated from diverse environmental samples that feed on other microbes for their survival and growth. However, no reports of cultured representatives from the human gut have been published to date, although previous investigations have revealed the presence of myxobacterial operational taxonomic units (OTUs) in skin and fecal samples. In this study, three myxobacterial strains designated as O35, O15, and Y35 were isolated and purified from fecal samples of two inflammatory bowel disease (IBD) patients. The 16S rRNA gene sequence analysis and phylogeny identified the strains as Myxococcus spp. belonging to two different clades. Genome-based phylogeny and overall genome-related indices, i.e., average amino acid identity and percentage of conserved proteins, confirmed the heterogeneity within the genus and placed the three strains within two different clades separated at the level of different genera. Digital DNA-DNA hybridization and average nucleotide identity values indicated that they belonged to two novel Myxococcus spp. The analysis of meta-barcoding data from IBD and control cohorts detected OTU lineages closely affiliated to the three novel strains. Based on evidence from detailed structural and functional genomics, we propose the novel species Myxococcus faecalis sp. nov. O35T and a new genus Pseudomyxococcus gen. nov. to accommodate the novel species Pseudomyxococcus flavus sp. nov. Y35T. Overall, these findings provide new information about the occurrence of myxobacteria in the human gut and lay the foundations for a new classification scheme for myxobacterial taxa.IMPORTANCEMyxobacteria have been described from a variety of niches ranging from terrestrial to marine habitats and are known to harbor a diverse portfolio of bioactive molecules. However, to date, there has been no report of isolating culturable representatives from the human gut. This study describes novel myxobacteria from the hu…
date: 2025-07
volume: 13
issue: 7
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository

American Society for Microbiology
type: Organization

Microbiol. Spectr.
type: Collection

Shiva S Sundharam
type: Person
given name: Shiva S
family name: Sundharam

S K Sinha
type: Person
given name: S K
family name: Sinha

Shilpee Pal
type: Person
given name: Shilpee
family name: Pal

Anu Negi
type: Person
given name: Anu
family name: Negi

Srinivasan Krishnamurthi
type: Person
given name: Srinivasan
family name: Krishnamurthi

Joyasree Das
type: Person
given name: Joyasree
family name: Das

Jayanta Samanta
type: Person
given name: Jayanta
family name: Samanta

Amit Yadav
type: Person
given name: Amit
family name: Yadav

Srikrishna Subramanian
type: Person
given name: Srikrishna
family name: Subramanian

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primary topic: Genomic insights into novel predatory myxobacteria isolated from human feces