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<http://crdd.osdd.net/open/3217/>
	dc:format "text/html";
	dc:title "HTML Summary of #3217 \n\nVisualizing gaussian-chain like structural models of human α-synuclein in monomeric pre-fibrillar state: Solution SAXS data and modeling analysis\n\n";
	foaf:primaryTopic <http://crdd.osdd.net/open/id/eprint/3217> .

<http://crdd.osdd.net/open/id/eprint/3217#authors>
	rdf:_1 <http://crdd.osdd.net/open/id/person/ext-303ec6f51b27921247c02ed91443b6fd>;
	rdf:_2 <http://crdd.osdd.net/open/id/person/ext-b7ab701e9957702b20e5535f3037ad1b>;
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	rdf:_5 <http://crdd.osdd.net/open/id/person/ext-63bb04ee8fb0725230fbfc7eace1b2fd> .

<http://crdd.osdd.net/open/id/eprint/3217>
	bibo:abstract "Here, using small angle X-ray scattering (SAXS) data profile as reference, we attempted to visualize conformational ensemble accessible prefibrillar monomeric state of α-synuclein in solution. In agreement with previous reports, our analysis also confirmed that α-synuclein molecules adopted disordered shape profile under non-associating conditions. Chain-ensemble modeling protocol with dummy residues provided two weighted averaged clusters of semi-extended shapes. Further, Ensemble Optimization Method (EOM) computed mole fractions of semi-extended ``twisted'' conformations which might co-exist in solution. Since these were only Cα traces of the models, ALPHAFOLD2 server was used to search for all-atom models. Comparison with experimental data showed all predicted models disagreed equally, as individuals. Finally, we employed molecular dynamics simulations and normal mode analysis-based search coupled with SAXS data to seek better agreeing models. Overall, our analysis concludes that a shifting equilibrium of curved models with low α-helical content best-represents non-associating monomeric α-synuclein."^^xsd:string;
	bibo:authorList <http://crdd.osdd.net/open/id/eprint/3217#authors>;
	bibo:issue "138614";
	bibo:volume "288";
	dct:creator <http://crdd.osdd.net/open/id/person/ext-63bb04ee8fb0725230fbfc7eace1b2fd>,
		<http://crdd.osdd.net/open/id/person/ext-303ec6f51b27921247c02ed91443b6fd>,
		<http://crdd.osdd.net/open/id/person/ext-b7ab701e9957702b20e5535f3037ad1b>,
		<http://crdd.osdd.net/open/id/person/ext-bc2daa5da94f9cc52613b2df301d9c5c>,
		<http://crdd.osdd.net/open/id/person/ext-d1a18832677225c00794fb52cc08b377>;
	dct:date "2025-02";
	dct:isPartOf <http://crdd.osdd.net/open/id/repository>,
		<http://crdd.osdd.net/open/id/publication/ext-ea24448f1edfdabdb10db53d878610bc>;
	dct:publisher <http://crdd.osdd.net/open/id/org/ext-464ff5f0fac4572c5372d3e7fc978be1>;
	dct:title "Visualizing gaussian-chain like structural models of human α-synuclein in monomeric pre-fibrillar state: Solution SAXS data and modeling analysis"^^xsd:string;
	rdf:type bibo:AcademicArticle,
		bibo:Article,
		ep:ArticleEPrint,
		ep:EPrint;
	rdfs:seeAlso <http://crdd.osdd.net/open/3217/> .

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	foaf:name "Elsevier BV"^^xsd:string;
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	foaf:name "Deepak Sharma"^^xsd:string;
	rdf:type foaf:Person .

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	foaf:familyName "Dey"^^xsd:string;
	foaf:givenName "Madhumita"^^xsd:string;
	foaf:name "Madhumita Dey"^^xsd:string;
	rdf:type foaf:Person .

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	foaf:familyName "Badmalia"^^xsd:string;
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	foaf:name "Maulik D Badmalia"^^xsd:string;
	rdf:type foaf:Person .

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	foaf:name "Int. J. Biol. Macromol."^^xsd:string;
	rdf:type bibo:Collection .