<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Visualizing gaussian-chain like structural models of human α-synuclein in monomeric pre-fibrillar state: Solution SAXS data and modeling analysis"^^ . "Here, using small angle X-ray scattering (SAXS) data profile as reference, we attempted to visualize conformational ensemble accessible prefibrillar monomeric state of α-synuclein in solution. In agreement with previous reports, our analysis also confirmed that α-synuclein molecules adopted disordered shape profile under non-associating conditions. Chain-ensemble modeling protocol with dummy residues provided two weighted averaged clusters of semi-extended shapes. Further, Ensemble Optimization Method (EOM) computed mole fractions of semi-extended ``twisted'' conformations which might co-exist in solution. Since these were only Cα traces of the models, ALPHAFOLD2 server was used to search for all-atom models. Comparison with experimental data showed all predicted models disagreed equally, as individuals. Finally, we employed molecular dynamics simulations and normal mode analysis-based search coupled with SAXS data to seek better agreeing models. Overall, our analysis concludes that a shifting equilibrium of curved models with low α-helical content best-represents non-associating monomeric α-synuclein."^^ . "2025-02" . "288" . "138614" . . "Elsevier BV"^^ . . . "Int. J. Biol. Macromol."^^ . . . . . . . . . . . . . . . . . . "Deepak"^^ . "Sharma"^^ . "Deepak Sharma"^^ . . "Arpit"^^ . "Gupta"^^ . "Arpit Gupta"^^ . . "Maulik D"^^ . "Badmalia"^^ . "Maulik D Badmalia"^^ . . "Madhumita"^^ . "Dey"^^ . "Madhumita Dey"^^ . . ""^^ . "Ashish"^^ . " Ashish"^^ . . . . . "HTML Summary of #3217 \n\nVisualizing gaussian-chain like structural models of human α-synuclein in monomeric pre-fibrillar state: Solution SAXS data and modeling analysis\n\n" . "text/html" . .