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primary topic: ARKbase: Antimicrobial resistance Knowledgebase1.0

ARKbase: Antimicrobial resistance Knowledgebase1.0
type: AcademicArticle
type: Article
abstract: Antimicrobial resistance (AMR) is one of the most pressing global health challenges, often referred to as a 'silent pandemic.' Towards this, ARKbase is developed as an integrated, curated, value-added knowledgebase for AMR, with focus on WHO Bacterial Priority Pathogens. ARKbase has three core modules namely-Database, Insight, and Comparative Analysis Module-each offering curated data, including data analysed with custom-built pipelines. The Database Module has curated reference genomes and pan genomes along with antimicrobial susceptibility testing (AST) profiles. The Insight Module has 14 sub-modules and offers deep annotations encompassing antimicrobial resistance genes, virulence factors, structure annotation, host-pathogen interactions, biosynthetic gene clusters, known antibiotics, protein-protein interactions, drug targets, co-targets, drug-target interactions, machine learning models, and curated transcriptomic datasets for antibiotic exposure. The Comparative Analysis module offers a simple interface for comparing antimicrobial resistance genes, virulence factors, and drug targets among different priority pathogens. The data included in ARKbase are quality-checked and curated as per CLSI standards for AST, EUCAST guidelines for genome sequence, and the FAIR data principles. ARKbase is the first comprehensive knowledgebase focusing on WHO priority pathogens and AWaRe classification, enabling a combined evidence approach towards a holistic understanding of AMR. Available at https://datascience.imtech.res.in/anshu/arkbase.
date: 2025
volume: 54
issue: D1
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
subject: QR Microbiology

Oxford University Press (OUP)
type: Organization

Nucleic Acids Res.
type: Collection

Rupali Aggarwal
type: Person
given name: Rupali
family name: Aggarwal

Suhani Dange
type: Person
given name: Suhani
family name: Dange

Anshu Bhardwaj
type: Person
given name: Anshu
family name: Bhardwaj

Shivani Seth
type: Person
given name: Shivani
family name: Seth

Harsh Bajetha
type: Person
given name: Harsh
family name: Bajetha

Gnanasekar Pranavathiyani
type: Person
given name: Gnanasekar
family name: Pranavathiyani

Jasleen Kaur
type: Person
given name: Jasleen
family name: Kaur

Vipin Singh
type: Person
given name: Vipin
family name: Singh

Shweta Pandey
type: Person
given name: Shweta
family name: Pandey

Upasana Maity
type: Person
given name: Upasana
family name: Maity

Bhupender Singh
type: Person
given name: Bhupender
family name: Singh

Mayur Zarkar
type: Person
given name: Mayur
family name: Zarkar

Ankita Das
type: Person
given name: Ankita
family name: Das

Simran Gambhir
type: Person
given name: Simran
family name: Gambhir

Raghav Sankhdher
type: Person
given name: Raghav
family name: Sankhdher

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primary topic: ARKbase: Antimicrobial resistance Knowledgebase1.0

QR Microbiology
type: Concept