<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Chemically synthesized LRAD3-D1 interacts with N-terminal domain of SARS-CoV-2 spike protein"^^ . "Growing evidence of post-COVID neurological complications, such as encephalopathy, neurodegeneration, and cognitive impairment, suggests severe acute respiratory syndrome-related corona virus 2 (SARS-CoV-2) viral infection into the central nervous system (CNS). Therefore, understanding the mechanisms of viral entry into the CNS, where human angiotensin-converting enzyme 2 (ACE2) is barely expressed, is critical for addressing the neurological consequences of COVID-19. Importantly, the low-density lipoprotein receptor class A domain containing 3 (LRAD3) is overexpressed in brain cells, suggesting a possible ACE2-independent alternate pathway of viral entry into brain cells. Herein, the interaction of the chemically synthesized LRAD3 domains with SARS-CoV-2 spike protein is reported. It is observed that the extracellular domains of LRAD3 depend on calcium for proper folding and maintaining their structural integrity. The results reveal that domain 1 of LRAD3, which is most accessible from the cell surface, engages with the N-terminal domain of the viral spike protein. These findings open up possibilities to develop new therapeutic strategies targeting ACE2 independent viral entry pathways."^^ . "2025-11" . "26" . "22" . . "Wiley"^^ . . . "Chembiochem"^^ . . . . . . . . . . . . . . . . . . . . . "Arighna"^^ . "Sarkar"^^ . "Arighna Sarkar"^^ . . "Sreejith"^^ . "Raran-Kurussi"^^ . "Sreejith Raran-Kurussi"^^ . . "Rathina"^^ . "Delipan"^^ . "Rathina Delipan"^^ . . "Mrinmoy"^^ . "Jana"^^ . "Mrinmoy Jana"^^ . . "Kalyaneswar"^^ . "Mandal"^^ . "Kalyaneswar Mandal"^^ . . "Rajesh P"^^ . "Ringe"^^ . "Rajesh P Ringe"^^ . . . . . "HTML Summary of #3224 \n\nChemically synthesized LRAD3-D1 interacts with N-terminal domain of SARS-CoV-2 spike protein\n\n" . "text/html" . .