@article{open3227,
          volume = {27},
          number = {1},
           month = {November},
          author = {Varsha Kadian and Babu Lal Jangir and Pooja Dalal and Sunil Kumar and Anroop Nair and Sweta Dalal and Rekha Rao},
           title = {Novel capsaicin nanogel for arthritic pain and inflammation management: Formulation, in vitro, ex-vivo and in vivo assessment},
       publisher = {Springer Science and Business Media LLC},
            year = {2025},
         journal = {AAPS PharmSciTech},
           pages = {31},
        keywords = {Carrageenan; Freud's complete adjuvant; Nanosponges; Skin permeation; {\ensuremath{\beta}}-cyclodextrin},
             url = {http://crdd.osdd.net/open/3227/},
        abstract = {The present work aimed to prepare and evaluate novel capsaicin (CAP) loaded nanosponges (NS) embedded Carbopol hydrogel (CAPNS-HG) with rosemary oil (RO) for arthritis management. CAP loaded NS were formulated using melt technique employing diphenylcarbonate and {\ensuremath{\beta}}-cyclodextrin. To facilitate their dermal application, CAPNS were integrated with Carbopol 934 hydrogel using RO as a permeation enhancer. Nanogel samples so formed were analyzed for physicochemical and rheological properties, followed by their in vitro, ex vivo, and in vivo evaluations. Based on the findings herein, CAPNS-HG was found to exhibit favorable rheological characteristics (610.56 cP), effective skin permeation (31.410 {$\pm$} 1.145 {\^A}?g/cm2), and delayed-release (61.91\% in 24 h). Further, the hydrogel was observed to follow Korsmeyer-Peppas release kinetics with the Fickian diffusion mechanism. Outcomes of the in vitro irritation study demonstrated that CAPNS-HG significantly reduced skin irritation (four times; CAP-HG 12.159 {$\pm$} 2.502 and CAPNS-HG 03.497 {$\pm$} 0.096), which was also validated from in vivo evaluations. Further, a remarkable decrease in inflammation (20.869 {$\pm$} 0.13\%) was noted in FCA-induced arthritic animals. Improved hematological profile along with histological and X-ray data substantiated reduction in arthritic symptoms in CAPNS-HG treated animals. Hence, it can be concluded from the findings that CAPNS-HG is a safer and more promising delivery option for alleviating complete FCA-induced symptoms. The combination of CAPNS with hydrogel further augmented the therapeutic efficiency, resulting in a novel formulation for pain and inflammation management in this chronic disorder.}
}