{
      "number": 1,
      "eprintid": 3227,
      "date": "2025-11",
      "userid": 2,
      "rev_number": 3,
      "creators": [
        {
          "name": {
            "lineage": null,
            "given": "Varsha",
            "honourific": null,
            "family": "Kadian"
          }
        },
        {
          "name": {
            "lineage": null,
            "given": "Babu Lal",
            "honourific": null,
            "family": "Jangir"
          }
        },
        {
          "name": {
            "lineage": null,
            "given": "Pooja",
            "honourific": null,
            "family": "Dalal"
          }
        },
        {
          "name": {
            "lineage": null,
            "given": "Sunil",
            "honourific": null,
            "family": "Kumar"
          }
        },
        {
          "name": {
            "lineage": null,
            "given": "Anroop",
            "honourific": null,
            "family": "Nair"
          }
        },
        {
          "name": {
            "lineage": null,
            "given": "Sweta",
            "honourific": null,
            "family": "Dalal"
          }
        },
        {
          "name": {
            "lineage": null,
            "given": "Rekha",
            "honourific": null,
            "family": "Rao"
          }
        }
      ],
      "dir": "disk0\/00\/00\/32\/27",
      "keywords": "Carrageenan; Freud's complete adjuvant; Nanosponges; Skin permeation; β-cyclodextrin",
      "lastmod": "2026-02-01 14:18:24",
      "pagerange": 31,
      "publisher": "Springer Science and Business Media LLC",
      "metadata_visibility": "show",
      "eprint_status": "archive",
      "status_changed": "2026-02-01 14:18:24",
      "volume": 27,
      "datestamp": "2026-02-01 14:18:24",
      "uri": "http:\/\/crdd.osdd.net\/open\/id\/eprint\/3227",
      "type": "article",
      "title": "Novel capsaicin nanogel for arthritic pain and inflammation management: Formulation, in vitro, ex-vivo and in vivo assessment",
      "abstract": "The present work aimed to prepare and evaluate novel capsaicin (CAP) loaded nanosponges (NS) embedded Carbopol hydrogel (CAPNS-HG) with rosemary oil (RO) for arthritis management. CAP loaded NS were formulated using melt technique employing diphenylcarbonate and β-cyclodextrin. To facilitate their dermal application, CAPNS were integrated with Carbopol 934 hydrogel using RO as a permeation enhancer. Nanogel samples so formed were analyzed for physicochemical and rheological properties, followed by their in vitro, ex vivo, and in vivo evaluations. Based on the findings herein, CAPNS-HG was found to exhibit favorable rheological characteristics (610.56 cP), effective skin permeation (31.410 ± 1.145 µg\/cm2), and delayed-release (61.91% in 24 h). Further, the hydrogel was observed to follow Korsmeyer-Peppas release kinetics with the Fickian diffusion mechanism. Outcomes of the in vitro irritation study demonstrated that CAPNS-HG significantly reduced skin irritation (four times; CAP-HG 12.159 ± 2.502 and CAPNS-HG 03.497 ± 0.096), which was also validated from in vivo evaluations. Further, a remarkable decrease in inflammation (20.869 ± 0.13%) was noted in FCA-induced arthritic animals. Improved hematological profile along with histological and X-ray data substantiated reduction in arthritic symptoms in CAPNS-HG treated animals. Hence, it can be concluded from the findings that CAPNS-HG is a safer and more promising delivery option for alleviating complete FCA-induced symptoms. The combination of CAPNS with hydrogel further augmented the therapeutic efficiency, resulting in a novel formulation for pain and inflammation management in this chronic disorder.",
      "publication": "AAPS PharmSciTech"
    }