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primary topic: Plasmonic photothermal based quick sterilization of surgical tools and pathogen suspensions

Plasmonic photothermal based quick sterilization of surgical tools and pathogen suspensions
type: AcademicArticle
type: Article
abstract: This study investigates the efficacy of plasmonic photothermal technique for quick sterilization of surgical tools and pathogen suspensions for the elimination of a high load of broad-spectrum pathogens viz. ESKAPE pathogens - Candida albicans (5 × 107 CFU/mL of each pathogen). Here, the contaminated surgical tools and the corresponding pathogens suspension to be sterilized, are irradiated with electromagnetic radiation (Visible-NIR) in the presence of synthesized triangular silver nanoplates leading to localized heat generation through plasmonic photothermal phenomenon. The irradiation source including the sterilization device prototype is developed In-house and is used for the sterilization of reusable surgical tools. The sterilization is achieved at lower temperatures of â�¼65-70 °C, at atmospheric pressure within 10 min of total duration. Also, sterility of the nanoplates suspension after a treatment cycle is confirmed for its re-use for multiple subsequent sterilization cycles. The demonstrated sterilization efficacy â�¼7.69 Log10 reductions of each pathogen, meets the required sterility assurance level (SAL) norms of 6 Log10 reduction. Further, the mechanism behind sterilization efficacy of plasmonic photothermal technique shows the morphological alterations & membrane lysis along with the combined impact of reactive oxygen species (ROS), which disrupts cellular metabolic pathways within the cells. In-vivo investigation of the use of a surgical blade sterilized through plasmonic photothermal technique, on BALB/C mice, further strengthens the real-time application and safety. Contrary to the antimicrobial studies reported in literature for such phenomenon, as far as we are aware, it is the first reported instance of the sterilization for reusable surgical tools through plasmonic photothermal technique.
date: 2025-11
volume: 272
issue: 113286
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository

Elsevier BV
type: Organization

J. Photochem. Photobiol. B
type: Collection

Vrushali Raka
type: Person
given name: Vrushali
family name: Raka

Parminder Kaur
type: Person
given name: Parminder
family name: Kaur

Sanjeev Soni
type: Person
given name: Sanjeev
family name: Soni

Rajneesh Dadwal
type: Person
given name: Rajneesh
family name: Dadwal

Hemraj Nandanwar
type: Person
given name: Hemraj
family name: Nandanwar

Shobit Attery
type: Person
given name: Shobit
family name: Attery

Sarabjot Kaur
type: Person
given name: Sarabjot
family name: Kaur

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primary topic: Plasmonic photothermal based quick sterilization of surgical tools and pathogen suspensions