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primary topic: Mycobacterium tuberculosis Acr1 protein mitigates experimental autoimmune encephalomyelitis symptoms by generating myeloid-derived suppressor cells and regulatory T cells

Mycobacterium tuberculosis Acr1 protein mitigates experimental autoimmune encephalomyelitis symptoms by generating myeloid-derived suppressor cells and regulatory T cells
type: AcademicArticle
type: Article
abstract: Mycobacterium tuberculosis (Mtb) effectively suppresses host immunity to ensure its survival. We have earlier shown that the Acr1 protein of Mtb can inhibit the differentiation of dendritic cells (DCs). Consequently, in the current study, we examined the role of Acr1 in mitigating autoimmunity. Initially, we observed that Acr1 skews the differentiation of DCs into functionally competent myeloid-derived suppressor cells (MDSCAcr1) that chiefly secrete immunosuppressive molecules, expand regulatory T cells (TregAcr1) and attenuate inflammatory responses. Further, MDSCAcr1 suppress Th17 cells. Acr1 expanded MDSCs with a concurrent increase in myelin oligodendrocyte glycoprotein (MOG)-specific Tregs and a decline in Th17 cells in a murine experimental autoimmune encephalomyelitis (EAE) model and prevented the onset of the disease. These results were further validated in the prophylactic model of EAE. Mechanistically, Acr1 activates Tregs and MDSCs via the TLR-4 pathway, implicating innate immune recognition in Mtb-induced suppression. The results indicate a potential role of Acr1 against autoimmune diseases.
date: 2025
volume: 177
issue: 2
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
subject: QR Microbiology

Wiley
type: Organization

Immunology
type: Collection

Mohammad Shaaz
type: Person
given name: Mohammad
family name: Shaaz

Javed N Agrewala
type: Person
given name: Javed N
family name: Agrewala

Mohd Affan Khan
type: Person
given name: Mohd Affan
family name: Khan

Kaneez F Siddiqui
type: Person
given name: Kaneez F
family name: Siddiqui

Junaid A Malik
type: Person
given name: Junaid A
family name: Malik

Mohammad Adeel Zafar
type: Person
given name: Mohammad Adeel
family name: Zafar

Shivank Prajapati
type: Person
given name: Shivank
family name: Prajapati

Taruna Lamba
type: Person
given name: Taruna
family name: Lamba

Ashish Arora
type: Person
given name: Ashish
family name: Arora

Sidhanta Nanda
type: Person
given name: Sidhanta
family name: Nanda

Sharvan Sehrawat
type: Person
given name: Sharvan
family name: Sehrawat

Sanpreet Singh
type: Person
given name: Sanpreet
family name: Singh

Sudhakar Singh
type: Person
given name: Sudhakar
family name: Singh

HTML Summary of #3242 Mycobacterium tuberculosis Acr1 protein mitigates experimental autoimmune encephalomyelitis symptoms by generating myeloid-derived suppressor cells and regulatory T cells
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primary topic: Mycobacterium tuberculosis Acr1 protein mitigates experimental autoimmune encephalomyelitis symptoms by generating myeloid-derived suppressor cells and regulatory T cells

QR Microbiology
type: Concept