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primary topic: The endoplasmic reticulum protein FAM134B acts as a regulator of mitochondrial morphology

The endoplasmic reticulum protein FAM134B acts as a regulator of mitochondrial morphology
type: AcademicArticle
type: Article
abstract: The endoplasmic reticulum (ER) and mitochondria are known to affect myriad cellular mechanisms processes. More recently, dynamic association between them has been identified in different eukaryotes; these interactions vary in their composition and involvement in regulation of intracellular machineries. FAM134B (also known as RETREG1), originally identified as an oncogene, regulates ER membrane shape and curvature. It is a key ER-phagy or reticulophagy receptor, which promotes autophagy of not only the ER but also simultaneous dual autophagy of ER and mitochondria. Although it is known that FAM134B can potentiate contact with mitochondria, its direct involvement in affecting mitochondrial dynamics remains unexplored. Here, we show that FAM134B can interact with the canonical fission-promoting protein DRP1 (also known as DNM1L). Functional depletion of FAM134B leads to local actin rearrangement and reduced DRP1 recruitment onto mitochondria, resulting in hyperfusion. A decrease in FAM134B levels is observed with aging in rat brains, cell and mouse models of Parkinson's disease and samples derived from individuals with disease. Our study establishes FAM134B as the ER partner that helps in maintaining mitochondrial morphology and dynamics.
date: 2025-11
volume: 138
issue: 22
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository

The Company of Biologists
type: Organization

J. Cell Sci.
type: Collection

Arpit Tyagi
type: Person
given name: Arpit
family name: Tyagi

Sebabrata Maity
type: Person
given name: Sebabrata
family name: Maity

Rupsha Mondal
type: Person
given name: Rupsha
family name: Mondal

Anwesha Dutta Gupta
type: Person
given name: Anwesha
family name: Dutta Gupta

Saikat Chakrabarti
type: Person
given name: Saikat
family name: Chakrabarti

Rajdeep Das
type: Person
given name: Rajdeep
family name: Das

Oishee Chakrabarti
type: Person
given name: Oishee
family name: Chakrabarti

Joy Chakraborty
type: Person
given name: Joy
family name: Chakraborty

Izaz Monir Kamal
type: Person
given name: Izaz Monir
family name: Kamal

Deepak Sharma
type: Person
given name: Deepak
family name: Sharma

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primary topic: The endoplasmic reticulum protein FAM134B acts as a regulator of mitochondrial morphology