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primary topic: Identification of SARS-CoV-2-binding lectins on a commercial lectin array

Identification of SARS-CoV-2-binding lectins on a commercial lectin array
type: AcademicArticle
type: Article
abstract: The Spike glycoprotein of SARS-CoV-2 is the major target for vaccines and therapeutics. Spike glycosylation is critical for ACE2 binding and subsequent viral fusion and entry. Here, we studied lectins for their ability to bind to SARS-CoV-2 Spike glycoprotein and SARS-CoV-2 virions by employing an array of 95 lectins, for 68 of which we predicted glycan-binding specificities using publically available glycan array data and MotifFinder software. We identified lectins with diverse glycan binding specificities that bound with high intensities to recombinant Spike and cultured SARS-CoV-2 virus - AAL, ABL, ACL, AMA, ASA, BANLEC, BC2L-A, RCA 120, CALSEPA, GAL3, GS-II, PALa, CA, HHA, PHA-L, PA-IIL, MNA-M, STL, LSL-N, GRFT, PSA, RS-FUC, PHA-E, CPA, LENTIL, RCA 60, GNA, ORYSATA, LcH A, PHA-P, PTL-2, MAA, Con A, TL, NPA, and SBA. Analyzing the glycan-binding specificities of these lectins, we predict that the Spike glycoprotein is modified with high mannose/hybrid N-glycans with terminal mannose residues, α1-6 core fucosylated N-glycans with terminal GlcNAc residues, and complex glycans with Lewis A, Lewis B, Lewis X, Lewis Y, and Blood group H structures on type-1 or type-2 extension sequences. The SARS-CoV-2-specific lectins identified in our study may be assessed for their antiviral potential in future studies.
date: 2025-07
volume: 15
issue: 1
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
subject: QR Microbiology

Springer Science and Business Media LLC
type: Organization

Sci. Rep.
type: Collection

Alka Rao
type: Person
given name: Alka
family name: Rao

Rajesh P Ringe
type: Person
given name: Rajesh P
family name: Ringe

Neetu
type: Person
family name: Neetu

T N C Ramya
type: Person
given name: T N C
family name: Ramya

Shimona Ahlawat
type: Person
given name: Shimona
family name: Ahlawat

Rathina Delipan
type: Person
given name: Rathina
family name: Delipan

HTML Summary of #3248 Identification of SARS-CoV-2-binding lectins on a commercial lectin array
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primary topic: Identification of SARS-CoV-2-binding lectins on a commercial lectin array

QR Microbiology
type: Concept