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primary topic: The dual implications of iron homeostasis as a bacterial threat: its roles in virulence and antimicrobial resistance

The dual implications of iron homeostasis as a bacterial threat: its roles in virulence and antimicrobial resistance
type: AcademicArticle
type: Article
abstract: Antimicrobial resistance (AMR) is a global health concern that requires innovative therapeutic strategies to improve clinical outcomes. Bacterial priority pathogens have developed multiple mechanisms for AMR. To develop therapeutics to overcome AMR, it is essential to explore, understand, and identify effective molecular targets. Iron is crucial for survival and pathogenesis in bacterial physiology. Reports indicate that iron supports vital cellular functions and modulates bacterial virulence and pathogenicity. Due to the bacterial requirement for iron during infection, antimicrobials are being developed by targeting iron homeostasis pathways in pathogens. In this review, we explore the virulence, AMR, and iron homeostatic mechanisms in bacterial pathogens, as well as the functional role of iron in regulating virulence, antimicrobial resistance, and other aspects of bacterial physiology, to elucidate potential therapeutic strategies against drug-resistant pathogens. This review briefly discusses therapeutic interventions based on iron homeostasis mechanisms and the associated translational challenges.
date: 2025-12
volume: 208
issue: 1
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository

Springer Science and Business Media LLC
type: Organization

Arch. Microbiol.
type: Collection

Balvinder Singh
type: Person
given name: Balvinder
family name: Singh

Govindan Rajamohan
type: Person
given name: Govindan
family name: Rajamohan

Vijaya Bharathi Srinivasan
type: Person
given name: Vijaya Bharathi
family name: Srinivasan

Chankit Giri
type: Person
given name: Chankit
family name: Giri

Naveenraj Rajasekar
type: Person
given name: Naveenraj
family name: Rajasekar

Karthikeyan Krishnan
type: Person
given name: Karthikeyan
family name: Krishnan

Mahesh Kumar
type: Person
given name: Mahesh
family name: Kumar

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primary topic: The dual implications of iron homeostasis as a bacterial threat: its roles in virulence and antimicrobial resistance