<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "PPARγ mediated enhanced lipid biogenesis fuels Mycobacterium tuberculosis growth in a drug-tolerant hepatocyte environment"^^ . "Mycobacterium tuberculosis (Mtb) infection of the lungs, besides producing prolonged cough with mucus, also causes progressive fatigue and cachexia with debilitating loss of muscle mass. While anti-tuberculosis (TB) drug therapy is directed toward eliminating bacilli, the treatment regimen ignores the systemic pathogenic derailments that probably dictate TB-associated mortality and morbidity. Presently, it is not understood whether Mtb spreads to metabolic organs and brings about these impairments. Here, we show that Mtb creates a replication-conducive milieu of lipid droplets in hepatocytes by upregulating transcription factor PPARγ and scavenging lipids from the host cells. In hepatocytes, Mtb shields itself against the common anti-TB drugs by inducing drug-metabolizing enzymes. Infection of the hepatocytes in the in vivo aerosol mice model can be consistently observed post-week, 4 along with enhanced expression of PPARγ and drug-metabolizing enzymes. Moreover, histopathological analysis indeed shows the presence of Mtb in hepatocytes along with granuloma-like structures in human biopsied liver sections. Hepatotropism of Mtb during the chronic infectious cycle results in immuno-metabolic dysregulation that could magnify local and systemic pathogenicity, altering clinical presentations."^^ . "2025-12" . "14" . "RP1038" . . "eLife Sciences Publications, Ltd"^^ . . . "Elife"^^ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "Aakash"^^ . "Chandramouli"^^ . "Aakash Chandramouli"^^ . . "Devram S"^^ . "Ghorpade"^^ . "Devram S Ghorpade"^^ . . "Siddhesh S"^^ . "Kamat"^^ . "Siddhesh S Kamat"^^ . . "Kritee"^^ . "Mehdiratta"^^ . "Kritee Mehdiratta"^^ . . "Mohit"^^ . "Yadav"^^ . "Mohit Yadav"^^ . . "Priya"^^ . "Sharma"^^ . "Priya Sharma"^^ . . "Binayak"^^ . "Sarkar"^^ . "Binayak Sarkar"^^ . . "Debasisa"^^ . "Mohanty"^^ . "Debasisa Mohanty"^^ . . "Rajesh S"^^ . "Gokhale"^^ . "Rajesh S Gokhale"^^ . . "Ashwani"^^ . "Kumar"^^ . "Ashwani Kumar"^^ . . "Raman Deep"^^ . "Sharma"^^ . "Raman Deep Sharma"^^ . . "Dhiraj"^^ . "Kumar"^^ . "Dhiraj Kumar"^^ . . "Jyotsna"^^ . "Singh"^^ . "Jyotsna Singh"^^ . . "Shweta"^^ . "Singh"^^ . "Shweta Singh"^^ . . . . . "HTML Summary of #3267 \n\nPPARγ mediated enhanced lipid biogenesis fuels Mycobacterium tuberculosis growth in a drug-tolerant hepatocyte environment\n\n" . "text/html" . .