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primary topic: A novel gellan-based nanoemulgel delivery system for co-encapsulation and in vitro digestion of hydrophilic/hydrophobic nutraceuticals

A novel gellan-based nanoemulgel delivery system for co-encapsulation and in vitro digestion of hydrophilic/hydrophobic nutraceuticals
type: AcademicArticle
type: Article
abstract: Preventive healthcare strategies are gaining attention over traditional approach of treating and managing diseases. The use of food hydrocolloids has garnered interest in developing innovative food formulations promoting healthy eating habits. Among emerging carrier systems, nanoemulgel holds significant potential with its ability to deliver hydrophilic and lipophilic nutraceuticals through a combination of nanoemulsion and hydrogel technology. For the first time, this study utilized gellan as an emulsifier and gelling agent to develop a novel nanoemulgel functional food system. Initially, a nanoemulsion composed of gellan and clove oil was prepared, having an average size of 40.10 ± 9.42 nm, which was stable under different physiological conditions. Further, nanoemulsion was combined with gellan hydrogel fabricated using Ê�-Glutamic acid as bio-linker to formulate nanoemulgel that was characterized thoroughly. We employed this system to co-encapsulate hydrophobic naringenin and hydrophilic vitamin B12. Additionally, encapsulation efficiency and release rate studies revealed high stability of bioactive at acidic pH. Moreover, release mechanism followed Korsmeyer-Peppas model and zero-order kinetics. During simulated in vitro digestion studies, site-directed release of nutraceuticals was observed. Therefore, present study represents a significant effort in developing novel functional food systems that aid in disease prevention and maintaining healthy lifestyle.
date: 2025-01
volume: 348
issue: Pt A
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository

Elsevier BV
type: Organization

Carbohydr. Polym.
type: Collection

Nandita Srivastava
type: Person
given name: Nandita
family name: Srivastava

Anirban Roy Choudhury
type: Person
given name: Anirban
family name: Roy Choudhury

Roshini Mohan
type: Person
given name: Roshini
family name: Mohan

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primary topic: A novel gellan-based nanoemulgel delivery system for co-encapsulation and in vitro digestion of hydrophilic/hydrophobic nutraceuticals