<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Understanding the combinatorial impact of amino acids as bio-linker on rheological behavior of gellan hydrogel blends"^^ . "Amino acids (AAs) can serve as essential bio-linkers due to their different functional groups, which may facilitate physical cross-linking in hydrogels. The mechanical properties of such hydrogels can be fine-tuned by varying the type and concentration of cross-linking agents. In this study, we developed novel gellan gum (GG) hydrogels by incorporating combinations of native AAs, including �-Arginine, �-Lysine, �-Glutamic acid, and �-Aspartic acid. These hydrogels exhibit thermo-reversible properties attributed to non-covalent interactions, enabling a gel-to-sol transition at temperatures above 37 °C owing to their upper critical solution temperature (UCST). Interestingly, these hydrogels were transparent, suggesting a uniform network structure. Moreover, they display a relatively low swelling capacity (10-25 %), indicating strong electrostatic interactions between AAs and GG. Rheological analyses highlight the significant role of AA combinations in modulating hydrogel behavior, showing improvements in shear-thinning, elasticity, self-healing, creep resistance, and overall mechanical performance. Mathematical modeling further supported these findings. Notably, mixtures containing �-Aspartic acid and �-Glutamic acid exhibited enhanced mechanical strength and stability, highlighting the importance of strategic cross-linker selection. These results demonstrate that tailoring cross-linkers can transform hydrogel properties, enabling the development of innovative materials for industrial applications."^^ . "2025-04" . "303" . "140686" . . "Elsevier BV"^^ . . . "Int. J. Biol. Macromol."^^ . . . . . . . . . "Anirban"^^ . "Roy Choudhury"^^ . "Anirban Roy Choudhury"^^ . . "Nandita"^^ . "Srivastava"^^ . "Nandita Srivastava"^^ . . . . . "HTML Summary of #3278 \n\nUnderstanding the combinatorial impact of amino acids as bio-linker on rheological behavior of gellan hydrogel blends\n\n" . "text/html" . .