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primary topic: GLYCOCINS: The sugar peppered antimicrobials

GLYCOCINS: The sugar peppered antimicrobials
type: AcademicArticle
type: Article
abstract: Glycosylated bacteriocins, known as glycocins, were first discovered in 2011. These bioactive peptides are produced by bacteria to gain survival advantages. They exhibit diverse types of glycans and demonstrate varied antimicrobial activity. Currently, there are 13 experimentally known glycocins, with over 250 identified in silico across different bacterial phyla. Notably, glycocins are recognized for their glycan-mediated antimicrobial activity, proving effective against drug-resistant and foodborne pathogens. Many glycocins contain rare S-linked glycans. Glycosyltransferases (GTs), responsible for transferring sugar to glycocins and involved in glycocin biosynthesis, often cluster together in the producer's genome. This clustering makes them valuable for custom glycoengineering with diverse substrate specificities. Heterologous expression of glycocins has paved the way for the establishment of microbial factories for glycopeptide and glycoconjugate production across various industries. In this review, we emphasize the primary roles of fully and partially characterized glycocins and their glycosylating enzymes. Additionally, we explore how specific glycan structures facilitate these functions in antibacterial activities. Furthermore, we discuss newer approaches and increasing efforts aimed at exploiting bacterial glycobiology for the development of food preservatives and as replacements or complements to traditional antibiotics, particularly in the face of antibiotic-resistant pathogenic bacteria.
date: 2024-10
volume: 75
issue: 108415
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository

Elsevier BV
type: Organization

Biotechnol. Adv.
type: Collection

Shimona Ahlawat
type: Person
given name: Shimona
family name: Ahlawat

Bhupendra Nath Shukla
type: Person
given name: Bhupendra Nath
family name: Shukla

Alka Rao
type: Person
given name: Alka
family name: Rao

Pravinkumar Choudhary
type: Person
given name: Pravinkumar
family name: Choudhary

Vaidhvi Singh
type: Person
given name: Vaidhvi
family name: Singh

Yogita Sharma
type: Person
given name: Yogita
family name: Sharma

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primary topic: GLYCOCINS: The sugar peppered antimicrobials