TY  - JOUR
ID  - open3299
UR  - http://crdd.osdd.net/open/3299/
IS  - 9
A1  - Ahmed, Momitul
A1  - Kurungottu, Pavithra
A1  - Swetha, K
A1  - Atla, Sandeep
A1  - Ashok, Nivethitha
A1  - Nagamalleswari, Easa
A1  - Bonam, Srinivasa Reddy
A1  - Sahu, Bidya Dhar
A1  - Kurapati, Rajendra
Y1  - 2025/04//
N2  - The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome is pivotal in orchestrating the immune response induced by nanoparticle adjuvants. Understanding the intricate mechanisms underlying the activation of NLRP3 inflammasome by these adjuvants is crucial for deciphering their immunomodulatory properties. This review explores the involvement of the NLRP3 inflammasome in mediating immune responses triggered by nanoparticle adjuvants. It delves into the signaling pathways and cellular mechanisms involved in NLRP3 activation, highlighting its significance in modulating the efficacy and safety of nanoparticle-based adjuvants. A comprehensive grasp of the interplay between NLRP3 inflammasome and nanoparticle adjuvants holds promise for optimizing vaccine design and advancing immunotherapeutic strategies.
PB  - Royal Society of Chemistry (RSC)
JF  - Biomater. Sci.
VL  - 13
TI  - Role of NLRP3 inflammasome in nanoparticle adjuvant-mediated immune response
SP  - 2164
EP  - 2178
ER  -