creators_name: Ahmed, Momitul
creators_name: Kurungottu, Pavithra
creators_name: Swetha, K
creators_name: Atla, Sandeep
creators_name: Ashok, Nivethitha
creators_name: Nagamalleswari, Easa
creators_name: Bonam, Srinivasa Reddy
creators_name: Sahu, Bidya Dhar
creators_name: Kurapati, Rajendra
type: article
datestamp: 2026-02-07 03:23:03
lastmod: 2026-02-07 03:23:03
metadata_visibility: show
title: Role of NLRP3 inflammasome in nanoparticle adjuvant-mediated immune response
abstract: The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome is pivotal in orchestrating the immune response induced by nanoparticle adjuvants. Understanding the intricate mechanisms underlying the activation of NLRP3 inflammasome by these adjuvants is crucial for deciphering their immunomodulatory properties. This review explores the involvement of the NLRP3 inflammasome in mediating immune responses triggered by nanoparticle adjuvants. It delves into the signaling pathways and cellular mechanisms involved in NLRP3 activation, highlighting its significance in modulating the efficacy and safety of nanoparticle-based adjuvants. A comprehensive grasp of the interplay between NLRP3 inflammasome and nanoparticle adjuvants holds promise for optimizing vaccine design and advancing immunotherapeutic strategies.
date: 2025-04
publication: Biomater. Sci.
volume: 13
number: 9
publisher: Royal Society of Chemistry (RSC)
pagerange: 2164-2178
citation:   Ahmed, Momitul and Kurungottu, Pavithra and Swetha, K and Atla, Sandeep and Ashok, Nivethitha and Nagamalleswari, Easa and Bonam, Srinivasa Reddy and Sahu, Bidya Dhar and Kurapati, Rajendra  (2025) Role of NLRP3 inflammasome in nanoparticle adjuvant-mediated immune response.  Biomater. Sci., 13 (9).  pp. 2164-2178.