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primary topic: ASLdC3: A derivative of acidic sophorolipid disrupts mitochondrial function, induces ROS generation, and inhibits biofilm formation in Candida albicans

ASLdC3: A derivative of acidic sophorolipid disrupts mitochondrial function, induces ROS generation, and inhibits biofilm formation in Candida albicans
type: AcademicArticle
type: Article
abstract: Fungal infections account for more than 140 million cases of severe and life-threatening conditions each year, causing approximately 1.7 million deaths annually. Candida albicans and related species are the most common human fungal pathogens, causing both superficial (mucosal and cutaneous) and life-threatening invasive infections (candidemia) with a 40-75% mortality rate. Among many virulence factors of Candida albicans, morphological transition from yeast to hyphae, secretion of hydrolytic enzymes, and formation of biofilms are considered to be crucial for pathogenicity. However, the arsenals for the treatment against these pathogens are restricted to only a few classes of approved drugs, the efficacy of which is being compromised by host toxicity, fungistatic activity, and the emergence of drug resistance. In this study, we have described the development of a molecule, exhibiting excellent antifungal activity (MIC 8 μg/mL), by tailoring acidic sophorolipids with aryl alcohols via enzyme catalysis. This novel derivative, ASLdC3, is a surface-active compound that lowers the surface tension of the air-water interface up to 2-fold before reaching the critical micelle concentration of 25 μg/mL. ASLdC3 exhibits excellent antibiofilm properties against Candida albicans and other nonalbicans Candida species. The molecule primarily exhibits its antifungal activity by perturbing mitochondrial function through the alteration of the mitochondrial membrane potential (MMP) and generation of reactive oxygen species (ROS). The ROS damages fungal cell membrane function and cell wall integrity, eventually leading to cell death. ASLdC3 was found to be nontoxic in in vitro assay and nonhemolytic. Besides, it does not cause toxicity in the C. elegans model. Our study provides a valuable foundation for the potential of acidic sophorolipid as a nontoxic, biodegradable precursor for the design and synthesis of novel molecules for use as antimicrobial drugs as well as for other clinical …
date: 2024-09
volume: 10
issue: 9
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository

American Chemical Society (ACS)
type: Organization

ACS Infect. Dis.
type: Collection

Sandal Deep Basotra
type: Person
given name: Sandal Deep
family name: Basotra

Mani Shankar Bhattacharyya
type: Person
given name: Mani Shankar
family name: Bhattacharyya

Deepak Sharma
type: Person
given name: Deepak
family name: Sharma

Mansi Vij
type: Person
given name: Mansi
family name: Vij

Arpit Tyagi
type: Person
given name: Arpit
family name: Tyagi

Yachna Kumari
type: Person
given name: Yachna
family name: Kumari

HTML Summary of #3300 ASLdC3: A derivative of acidic sophorolipid disrupts mitochondrial function, induces ROS generation, and inhibits biofilm formation in Candida albicans
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primary topic: ASLdC3: A derivative of acidic sophorolipid disrupts mitochondrial function, induces ROS generation, and inhibits biofilm formation in Candida albicans