…
comment: The repository administrator has not yet configured an RDF license.
primary topic: Synthetic indole derivatives as an antibacterial agent inhibiting respiratory metabolism of multidrug-resistant gram-positive bacteria

Synthetic indole derivatives as an antibacterial agent inhibiting respiratory metabolism of multidrug-resistant gram-positive bacteria
type: AcademicArticle
type: Article
abstract: The survival of modern medicine depends heavily on the effective prevention and treatment of bacterial infections, are threatened by antibacterial resistance. The increasing use of antibiotics and lack of stewardship have led to an increase in antibiotic-resistant pathogens, so the growing issue of resistance can be resolved by emphasizing chemically synthesized antibiotics. This study discovered SMJ-2, a synthetic indole derivative, is effective against all multidrug-resistant gram-positive bacteria. SMJ-2 has multiple targets of action, but the primary mechanism inhibits respiratory metabolism and membrane potential disruption. SMJ-2 was discovered to interfere with the mevalonate pathway, ultimately preventing the synthesis of farnesyl diphosphate, a precursor to the antioxidant staphyloxanthin, eventually releasing reactive oxygen species, and leading phagocytic cells to destroy pathogens. Additionally, no discernible biochemical and histopathological alterations were found in the mouse acute toxicity model. This study emphasizes mechanistic insights into SMJ-2 as a potential antibacterial with an unusual method of action.
date: 2024-11
volume: 7
issue: 1
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository

Springer Science and Business Media LLC
type: Organization

Commun. Biol.
type: Collection

Ritu Kalia
type: Person
given name: Ritu
family name: Kalia

Rushikesh Tambat
type: Person
given name: Rushikesh
family name: Tambat

Hemraj Nandanwar
type: Person
given name: Hemraj
family name: Nandanwar

Nisha Mahey
type: Person
given name: Nisha
family name: Mahey

Nishtha Chandal
type: Person
given name: Nishtha
family name: Chandal

Sanjay Jachak
type: Person
given name: Sanjay
family name: Jachak

Akash Dey
type: Person
given name: Akash
family name: Dey

HTML Summary of #3306 Synthetic indole derivatives as an antibacterial agent inhibiting respiratory metabolism of multidrug-resistant gram-positive bacteria
format: text/html
primary topic: Synthetic indole derivatives as an antibacterial agent inhibiting respiratory metabolism of multidrug-resistant gram-positive bacteria