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primary topic: Self-adhesive poly-l-lysine/tannic acid hybrid hydrogel for synergistic antibacterial activity against biofilms

Self-adhesive poly-l-lysine/tannic acid hybrid hydrogel for synergistic antibacterial activity against biofilms
type: AcademicArticle
type: Article
abstract: Biomedical implants are crucial for enhancing various human physiological functions. However, they are susceptible to microbial contamination after implantation, posing a risk of implant failure. To address this issue, hydrogel-based coatings are used, but achieving both effective antibacterial properties and stable adhesion remains challenging. This study introduces a hybrid hydrogel network made from Tannic Acid (TA) and Poly-l-Lysine (PLL), cross-linked through ionic and hydrogen bonds, which imparts adhesive and anti-infective properties. The physicochemical analysis revealed that the hydrogels exhibited significant porosity, favorable mechanical characteristics, and demonstrated in vitro enzymatic biodegradation. Moreover, the hydrogels demonstrated adhesion to various substrates, including Ti alloy with an adhesive strength of 42.5 kPa, and retained their integrity even after immersion in water for a minimum of 10 days. The modified Ti surfaces significantly reduced protein adsorption (â�¼70 %), indicating antifouling properties. The hydrogels prevented bacterial adhesion on titanium surfaces through a ``contact-kill'' mode of action and inhibited biofilm formation by around 94.5 % for Staphylococcus aureus and 90.8 % for Pseudomonas aeruginosa. The modified Ti retained biofilm inhibitory effects for at least six days without significant performance decline. In vitro cytotoxicity assay confirmed the biocompatibility of the hydrogels with NIH3T3 cells. Overall, these results highlight the competence of hybrid hydrogels as effective coatings for Ti implants, offering strong adhesion and biofilm prevention to mitigate implant-related infections.
date: 2024-10
volume: 278
issue: Pt 4
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository

Elsevier BV
type: Organization

Int. J. Biol. Macromol.
type: Collection

Anil Kumar Pinnaka
type: Person
given name: Anil Kumar
family name: Pinnaka

Deepak Kumar
type: Person
given name: Deepak
family name: Kumar

Deepa Garg
type: Person
given name: Deepa
family name: Garg

Abhay Sachdev
type: Person
given name: Abhay
family name: Sachdev

Ishita Matai
type: Person
given name: Ishita
family name: Matai

Sakshi Paliwal
type: Person
given name: Sakshi
family name: Paliwal

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primary topic: Self-adhesive poly-l-lysine/tannic acid hybrid hydrogel for synergistic antibacterial activity against biofilms