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primary topic: Invasive fungal infections in immunocompromised conditions: Emphasis on COVID-19

Invasive fungal infections in immunocompromised conditions: Emphasis on COVID-19
type: AcademicArticle
type: Article
abstract: The COVID-19 pandemic caused death of 6 million lives globally, primarily from respiratory failure, but also a significant number from invasive fungal co-infections in these patients, owing to the immune dysfunction in hospitalized patients. Such complications occurred more often in critically ill, hospitalized patients particularly those admitted in intensive care units and were reported as the major reason associated with a high mortality rate worldwide. Fungal pathogens most commonly associated with COVID-19 patients comprise members of the Mucorales (such as Rhizopus, Mucor, and Lichtheimia), as well as genera Aspergillus and Candida. In India, the prevalence rate of mucormycosis is relatively high than aspergillosis and candidiasis, and the predisposing risk factors associated with such infections included uncontrolled diabetes, underlying lung disease, leukopenia, neutropenia, malignancies and prolonged steroid therapy. However, co-infection with other fungi, including Alternaria and Scedosporium was also sporadically reported. These devastating invasive fungal infections are associated with differential mortality (high-low) and morbidity rates even after active management. The diagnosis of such infections is often challenging due to lack of sensitivity in contemporary diagnostic methods and poses an enormous challenge to healthcare experts. Thus, the role of early and accurate diagnosis, and management of such fungal infections, is vital in preventing life-threatening situations. Hence, this review focusses primarily on the epidemiology, predisposing risk factors, host environment, diagnosis and treatment of the most common medically important invasive fungal infections in immunocompromised conditions associated with COVID-19.
date: 2024-10
volume: 81
issue: 11
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository

Springer Science and Business Media LLC
type: Organization

Curr. Microbiol.
type: Collection

Vishakha Grover
type: Person
given name: Vishakha
family name: Grover

Devadatha Bandarupalli
type: Person
given name: Devadatha
family name: Bandarupalli

Stanzin Choksket
type: Person
given name: Stanzin
family name: Choksket

Harshvardhan
type: Person
family name: Harshvardhan

Payal Thakur
type: Person
given name: Payal
family name: Thakur

Nandini Verma
type: Person
given name: Nandini
family name: Verma

Suresh Korpole
type: Person
given name: Suresh
family name: Korpole

Mahaldeep Kaur
type: Person
given name: Mahaldeep
family name: Kaur

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primary topic: Invasive fungal infections in immunocompromised conditions: Emphasis on COVID-19