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primary topic: Theranostics: aptamer-assisted carbon nanotubes as MRI contrast and photothermal agent for breast cancer therapy

Theranostics: aptamer-assisted carbon nanotubes as MRI contrast and photothermal agent for breast cancer therapy
type: AcademicArticle
type: Article
abstract: Breast cancer is one of the leading causes of death among women globally, making its diagnosis and treatment challenging. The use of nanotechnology for cancer diagnosis and treatment is an emerging area of research. To address this issue, multiwalled carbon nanotubes (MWCNTs) were ligand exchanged with butyric acid (BA) to gain hydrophilic character. The successful functionalization was confirmed by FTIR spectroscopy. Surface morphology changes were observed using SEM, while TEM confirmed the structural integrity of the MWCNTs after functionalization. Particle size, zeta potential, and UV spectroscopy were also performed to further characterize the nanoparticles. The breast cancer aptamer specific to Mucin-1 (MUC-1) was then conjugated with the functionalized MWCNTs. These MWCNTs successfully targeted breast cancer cells (MDA-MB-231) as examined by cellular uptake studies and exhibited a reduction in cancer-induced inflammation, as evidenced by gene transcription (qPCR) and protein expression (immunoblotting) levels. Immunoblot and confocal-based immunofluorescence assay (IFA) indicated the ability of CNTs to induce photothermal cell death of MDA-MB-231 cells. Upon imaging, cancer cells were effectively visualized due to the MWCNTs' ability to act as magnetic resonance imaging (MRI) contrast agents. Additionally, MWCNTs demonstrated photothermal capabilities to eliminate bound cancer cells. Collectively, our findings pave the way for developing aptamer-labeled MWCNTs as viable ``theranostic alternatives'' for breast cancer treatment.
date: 2024-09
volume: 19
issue: 1
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository

Springer Science and Business Media LLC
type: Organization

Discov. Nano
type: Collection

Manisha Trivedi
type: Person
given name: Manisha
family name: Trivedi

Gurpal Singh
type: Person
given name: Gurpal
family name: Singh

Rajeev K Tyagi
type: Person
given name: Rajeev K
family name: Tyagi

Akanksha Sharma
type: Person
given name: Akanksha
family name: Sharma

Harinder Kaur
type: Person
given name: Harinder
family name: Kaur

Ashok Kumar Yadav
type: Person
given name: Ashok Kumar
family name: Yadav

Hema K Alajangi
type: Person
given name: Hema K
family name: Alajangi

Rajeev Singh Raghuvanshi
type: Person
given name: Rajeev Singh
family name: Raghuvanshi

Laxmi Kumari
type: Person
given name: Laxmi
family name: Kumari

Yong-Beom Lim
type: Person
given name: Yong-Beom
family name: Lim

Ravi Pratap Barnwal
type: Person
given name: Ravi Pratap
family name: Barnwal

Prakriti Sharma
type: Person
given name: Prakriti
family name: Sharma

Indu Pal Kaur
type: Person
given name: Indu Pal
family name: Kaur

Akhil Khajuria
type: Person
given name: Akhil
family name: Khajuria

Robin Kumar
type: Person
given name: Robin
family name: Kumar

Pradeep Kumar Jaiswal
type: Person
given name: Pradeep Kumar
family name: Jaiswal

Sushmita Negi
type: Person
given name: Sushmita
family name: Negi

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primary topic: Theranostics: aptamer-assisted carbon nanotubes as MRI contrast and photothermal agent for breast cancer therapy