TY  - JOUR
ID  - open3327
UR  - http://crdd.osdd.net/open/3327/
A1  - Malik, Jonaid Ahmad
A1  - Zafar, Mohammad Adeel
A1  - Singh, Sanpreet
A1  - Nanda, Sidhanta
A1  - Bashir, Hilal
A1  - Das, Deepjyoti Kumar
A1  - Lamba, Taruna
A1  - Khan, Mohammad Affan
A1  - Kaur, Gurpreet
A1  - Agrewala, Javed N
Y1  - 2024/10//
N2  - Autophagy is a fundamental pillar of cellular resilience, indispensable for maintaining cellular health and vitality. It coordinates the meticulous breakdown of cytoplasmic macromolecules as a guardian of cell metabolism, genomic integrity, and survival. In the complex play of biological warfare, autophagy emerges as a firm defender, bravely confronting various pathogenic, infectious, and cancerous adversaries. Nevertheless, its role transcends mere defense, wielding both protective and harmful effects in the complex landscape of disease pathogenesis. From the onslaught of infectious outbreaks to the devious progression of chronic lifestyle disorders, autophagy emerges as a central protagonist, convolutedly shaping the trajectory of cellular health and disease progression. In this article, we embark on a journey into the complicated web of molecular and immunological mechanisms that govern autophagy's profound influence over disease. Our focus sharpens on dissecting the impact of various autophagy-associated proteins on the kaleidoscope of immune responses, spanning the spectrum from infectious outbreaks to chronic lifestyle ailments. Through this voyage of discovery, we unveil the vast potential of autophagy as a therapeutic linchpin, offering tantalizing prospects for targeted interventions and innovative treatment modalities that promise to transform the landscape of disease management.
JF  - European Journal of Pharmacology
VL  - 981
KW  - Autophagy; Autoimmune diseases; Infectious diseases; lifestyle diseases
TI  - From defense to dysfunction: Autophagy's dual role in disease pathophysiology
ER  -