creators_name: Malik, Jonaid Ahmad
creators_name: Zafar, Mohammad Adeel
creators_name: Singh, Sanpreet
creators_name: Nanda, Sidhanta
creators_name: Bashir, Hilal
creators_name: Das, Deepjyoti Kumar
creators_name: Lamba, Taruna
creators_name: Khan, Mohammad Affan
creators_name: Kaur, Gurpreet
creators_name: Agrewala, Javed N
type: article
datestamp: 2026-02-07 04:49:41
lastmod: 2026-02-07 04:49:41
metadata_visibility: show
title: From defense to dysfunction: Autophagy's dual role in disease pathophysiology
keywords: Autophagy; Autoimmune diseases; Infectious diseases; lifestyle diseases
abstract: Autophagy is a fundamental pillar of cellular resilience, indispensable for maintaining cellular health and vitality. It coordinates the meticulous breakdown of cytoplasmic macromolecules as a guardian of cell metabolism, genomic integrity, and survival. In the complex play of biological warfare, autophagy emerges as a firm defender, bravely confronting various pathogenic, infectious, and cancerous adversaries. Nevertheless, its role transcends mere defense, wielding both protective and harmful effects in the complex landscape of disease pathogenesis. From the onslaught of infectious outbreaks to the devious progression of chronic lifestyle disorders, autophagy emerges as a central protagonist, convolutedly shaping the trajectory of cellular health and disease progression. In this article, we embark on a journey into the complicated web of molecular and immunological mechanisms that govern autophagy's profound influence over disease. Our focus sharpens on dissecting the impact of various autophagy-associated proteins on the kaleidoscope of immune responses, spanning the spectrum from infectious outbreaks to chronic lifestyle ailments. Through this voyage of discovery, we unveil the vast potential of autophagy as a therapeutic linchpin, offering tantalizing prospects for targeted interventions and innovative treatment modalities that promise to transform the landscape of disease management.
date: 2024-10
publication: European Journal of Pharmacology
volume: 981
pagerange: 176856
citation:   Malik, Jonaid Ahmad and Zafar, Mohammad Adeel and Singh, Sanpreet and Nanda, Sidhanta and Bashir, Hilal and Das, Deepjyoti Kumar and Lamba, Taruna and Khan, Mohammad Affan and Kaur, Gurpreet and Agrewala, Javed N  (2024) From defense to dysfunction: Autophagy's dual role in disease pathophysiology.  European Journal of Pharmacology, 981.  p. 176856.