…
comment: The repository administrator has not yet configured an RDF license.
primary topic: Oleuropein activates autophagy to circumvent anti-plasmodial defense

Oleuropein activates autophagy to circumvent anti-plasmodial defense
type: AcademicArticle
type: Article
abstract: Antimalarial drug resistance and unavailability of effective vaccine warrant for newer drugs and drug targets. Hence, anti-inflammatory activity of phyto-compound (oleuropein; OLP) was determined in antigen (LPS)-stimulated human THP-1 macrophages (macrophage model of inflammation; MMI). Reduction in the inflammation was controlled by the PI3K-Akt1 signaling to establish the ``immune-homeostasis.'' Also, OLP treatment influenced the cell death/autophagy axis leading to the modulated inflammation for extended cell survival. The findings with MII prompted us to detect the antimalarial activity of OLP in the wild type (3D7), D10-expressing GFP-Atg18 parasite, and chloroquine-resistant (Dd2) parasite. OLP did not show the parasite inhibition in the routine in vitro culture of P. falciparum whereas OLP increased the antimalarial activity of artesunate. The molecular docking of autophagy-related proteins, investigations with MMI, and parasite inhibition assays indicated that the host activated the autophagy to survive OLP pressure. The challenge model of P. berghei infection showed to induce autophagy for circumventing anti-plasmodial defenses.
date: 2024-04
volume: 27
issue: 4
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository

Elsevier BV
type: Organization

iScience
type: Collection

Neil Roy Chaudhary
type: Person
given name: Neil Roy
family name: Chaudhary

Praveen Sharma
type: Person
given name: Praveen
family name: Sharma

Sonia Devi
type: Person
given name: Sonia
family name: Devi

Nikunj Tandel
type: Person
given name: Nikunj
family name: Tandel

Sheetal Saini
type: Person
given name: Sheetal
family name: Saini

Bharat Singh Chandel
type: Person
given name: Bharat Singh
family name: Chandel

Prakriti Sharma
type: Person
given name: Prakriti
family name: Sharma

Puran S Sijwali
type: Person
given name: Puran S
family name: Sijwali

Rajinder Kumar
type: Person
given name: Rajinder
family name: Kumar

Rajeev K Tyagi
type: Person
given name: Rajeev K
family name: Tyagi

Sushmita Negi
type: Person
given name: Sushmita
family name: Negi

Kanika Saxena
type: Person
given name: Kanika
family name: Saxena

Reetesh Kumar
type: Person
given name: Reetesh
family name: Kumar

HTML Summary of #3341 Oleuropein activates autophagy to circumvent anti-plasmodial defense
format: text/html
primary topic: Oleuropein activates autophagy to circumvent anti-plasmodial defense