<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Epigenetic landscape of intestinal cell line HT29 cocultured with Lacticaseibacillus"^^ . "Aim: To investigate the changes in epigenetic landscape of HT29 cells upon coculture with the Lacticaseibacillus.Materials & methods: Histone and m6A mRNA modifications were examined by biochemical and NGS-based methods including western blotting, colorimetric assays, ChIP-Seq and direct mRNA sequencing. LC-MS was performed to identify Lacticaseibacillus secretome.Results: In cocultured HT29 cells global enrichment of H3K9ac and H3K4me3 and depletion of H3K9me3 mark was observed; mean genic positional signals showed depletion of H3K9ac and H3K4me3 at the TSS but enrichment in the upstream region; m6A methylation was altered in mRNAs corresponding to specific gene pathways; Lacticaseibacillus HU protein interacts with histone H3.Conclusion: Lacticaseibacillus can epigenetically alter specific genetic pathways in human intestinal cells."^^ . "2024-07" . "16" . "15-16" . . "Informa UK Limited"^^ . . . "Epigenomics"^^ . . . . . . . . . "Anunay"^^ . "Sinha"^^ . "Anunay Sinha"^^ . . "Sanjeev"^^ . "Khosla"^^ . "Sanjeev Khosla"^^ . . . . . "HTML Summary of #3349 \n\nEpigenetic landscape of intestinal cell line HT29 cocultured with Lacticaseibacillus\n\n" . "text/html" . .