primary topic: The opportunistic nature of gut commensal microbiota
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HTML Summary of #3366 The opportunistic nature of gut commensal microbiota
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primary topic: The opportunistic nature of gut commensal microbiota

The opportunistic nature of gut commensal microbiota
abstract: The abundance of gut commensals has historically been associated with health-promoting effects despite the fact that the definition of good or bad microbiota remains condition-specific. The beneficial or pathogenic nature of microbiota is generally dictated by the dimensions of host-microbiota and microbe-microbe interactions. With the increasing popularity of gut microbiota in human health and disease, emerging evidence suggests opportunistic infections promoted by those gut bacteria that are generally considered beneficial. Therefore, the current review deals with the opportunistic nature of the gut commensals and aims to summarise the concepts behind the occasional commensal-to-pathogenic transformation of the gut microbes. Specifically, relevant clinical and experimental studies have been discussed on the overgrowth and bacteraemia caused by commensals. Three key processes and their underlying mechanisms have been summarised to be responsible for the opportunistic nature of commensals, viz. improved colonisation fitness that is dictated by commensal-pathogen interactions and availability of preferred nutrients; pathoadaptive mutations that can trigger the commensal-to-pathogen transformation; and evasion of host immune response as a survival and proliferation strategy of the microbes. Collectively, this review provides an updated concept summary on the underlying mechanisms of disease causative events driven by gut commensal bacteria.
author list: authors
issue: 6
status: peerReviewed
status: published
volume: 49
date: 2023-11
is part of: repository
subject: QR Microbiology
type: AcademicArticle
type: Article
type: ArticleEPrint
type: EPrint

QR Microbiology
type: Concept

Informa UK Limited
type: Organization

Saumya Ray Chaudhuri
family name: Ray Chaudhuri
given name: Saumya
type: Person

Priyankar Dey
family name: Dey
given name: Priyankar
type: Person

Crit. Rev. Microbiol.
type: Collection