@prefix epid: .
@prefix dc: .
@prefix geo: .
@prefix bibo: .
@prefix owl: .
@prefix void: .
@prefix event: .
@prefix skos: .
@prefix xsd: .
@prefix cc: .
@prefix ep: .
@prefix foaf: .
@prefix rdf: .
@prefix rdfs: .
@prefix eprel: .
@prefix dct: .
<>
foaf:primaryTopic ;
rdfs:comment "The repository administrator has not yet configured an RDF license."^^xsd:string .
dc:format "text/html";
dc:title "HTML Summary of #3379 \n\nRecompensation of chronic hepatitis C-related decompensated cirrhosis following direct-acting antiviral therapy: Prospective cohort study from a hepatitis C virus elimination program\n\n";
foaf:primaryTopic .
rdf:_1 ;
rdf:_2 ;
rdf:_3 ;
rdf:_4 ;
rdf:_5 ;
rdf:_6 ;
rdf:_7 ;
rdf:_8 ;
rdf:_9 ;
rdf:_10 ;
rdf:_11 ;
rdf:_12 ;
rdf:_13 ;
rdf:_14 ;
rdf:_15 ;
rdf:_16 ;
rdf:_17 ;
rdf:_18 .
bibo:abstract "BACKGROUND & AIMS: Chronic hepatitis C-related decompensated cirrhosis is associated with lower sustained virologic response (SVR)-12 rates and variable regression of disease severity after direct-acting antiviral agents. We assessed rates of SVR-12, recompensation (Baveno VII criteria), and survival in such patients. METHODS: Between July 2018 and July 2023, patients with decompensated chronic hepatitis C-related cirrhosis after direct-acting antiviral agents treatment were evaluated for SVR-12 and then had 6-monthly follow-up. RESULTS: Of 6516 patients with cirrhosis, 1152 with decompensated cirrhosis (age 53.2 ± 11.5 years; 63% men; Model for End-stage Liver Disease-Sodium MELD-Na: 16.5 $\\pm$ 4.6; 87\\% genotype 3) were enrolled. SVR-12 was 81.8\\% after 1 course; ultimately SVR was 90.8\\% after additional treatment. Decompensation events included ascites (1098; 95.3\\%), hepatic encephalopathy (191; 16.6\\%), and variceal bleeding (284; 24.7\\%). Ascites resolved in 86\\% (diuretic withdrawal achieved in 24\\% patients). Recompensation occurred in 284 (24.7\\%) at a median time of 16.5 (interquartile range, 14.5-20.5) months. On multivariable Cox proportional hazards analysis, low bilirubin (adjusted hazard ratio aHR, 0.6; 95\\% confidence interval CI, 0.5-0.8; P < 0.001), international normalized ratio (aHR, 0.2; 95\\% CI, 0.1-0.3; P < 0.001), absence of large esophageal varices (aHR, 0.4; 95\\% CI, 0.2-0.9; P = 0.048), or gastric varices (aHR, 0.5; 95\\% CI, 0.3-0.7; P = 0.022) predicted recompensation. Portal hypertension progressed in 158 (13.7\\%) patients, with rebleed in 4\\%. Prior decompensation with variceal bleeding (aHR, 1.6; 95\\% CI, 1.2-2.8; P = 0.042), and presence of large varices (aHR, 2.9; 95\\% CI, 1.3-6.5; P < 0.001) were associated with portal hypertension progression. Further decompensation was seen in 221 (19\\%); 145 patients died and 6 underwent liver transplantation. A decrease in MELDNa of $\\geq$3 was seen in 409 (35.5\\%) and a final MELDNa score of <10 was seen in 335 (29\\%), but 2.9\\% developed hepatocellular carcinoma despite SVR-12. CONCLUSIONS: SVR-12 in hepatitis C virus-related decompensated cirrhosis in a predominant genotype 3 population led to recompensation in 24.7\\% of patients over a follow-up of 4 years in a public health setting. Despite SVR-12, new hepatic decompensation evolved in 19\\% and hepatocellular carcinoma developed in 2.9\\% of patients. (ClinicalTrials.gov, Number: NCT03488485)."^^xsd:string;
bibo:authorList ;
bibo:issue "7";
bibo:status ,
;
bibo:volume "167";
dct:creator ,
,
,
,
,
,
,
,
,
,
,
,
,
,
,
,
,
;
dct:date "2024-12-07";
dct:isPartOf ,
;
dct:publisher ;
dct:subject ;
dct:title "Recompensation of chronic hepatitis C-related decompensated cirrhosis following direct-acting antiviral therapy: Prospective cohort study from a hepatitis C virus elimination program"^^xsd:string;
rdf:type bibo:AcademicArticle,
bibo:Article,
ep:ArticleEPrint,
ep:EPrint;
rdfs:seeAlso .
rdf:type skos:Concept;
skos:prefLabel "QR Microbiology"@en .
foaf:name "Elsevier BV"^^xsd:string;
rdf:type foaf:Organization .
foaf:familyName "Rathi"^^xsd:string;
foaf:givenName "Sahaj"^^xsd:string;
foaf:name "Sahaj Rathi"^^xsd:string;
rdf:type foaf:Person .
foaf:familyName "Kulkarni"^^xsd:string;
foaf:givenName "Anand V"^^xsd:string;
foaf:name "Anand V Kulkarni"^^xsd:string;
rdf:type foaf:Person .
foaf:familyName "Gupta"^^xsd:string;
foaf:givenName "Ekta"^^xsd:string;
foaf:name "Ekta Gupta"^^xsd:string;
rdf:type foaf:Person .
foaf:familyName "Verma"^^xsd:string;
foaf:givenName "Nipun"^^xsd:string;
foaf:name "Nipun Verma"^^xsd:string;
rdf:type foaf:Person .
foaf:familyName "Chaluvashetty"^^xsd:string;
foaf:givenName "Sreedhara B"^^xsd:string;
foaf:name "Sreedhara B Chaluvashetty"^^xsd:string;
rdf:type foaf:Person .
foaf:familyName "Kalra"^^xsd:string;
foaf:givenName "Naveen"^^xsd:string;
foaf:name "Naveen Kalra"^^xsd:string;
rdf:type foaf:Person .
foaf:familyName "Dhiman"^^xsd:string;
foaf:givenName "Radha K"^^xsd:string;
foaf:name "Radha K Dhiman"^^xsd:string;
rdf:type foaf:Person .
foaf:familyName "Bhujade"^^xsd:string;
foaf:givenName "Harish"^^xsd:string;
foaf:name "Harish Bhujade"^^xsd:string;
rdf:type foaf:Person .
foaf:familyName "Nain"^^xsd:string;
foaf:givenName "Jasvinder"^^xsd:string;
foaf:name "Jasvinder Nain"^^xsd:string;
rdf:type foaf:Person .
foaf:familyName "Taneja"^^xsd:string;
foaf:givenName "Sunil"^^xsd:string;
foaf:name "Sunil Taneja"^^xsd:string;
rdf:type foaf:Person .
foaf:familyName "Grover"^^xsd:string;
foaf:givenName "Gagandeep S"^^xsd:string;
foaf:name "Gagandeep S Grover"^^xsd:string;
rdf:type foaf:Person .
foaf:familyName "Reddy"^^xsd:string;
foaf:givenName "K Rajender"^^xsd:string;
foaf:name "K Rajender Reddy"^^xsd:string;
rdf:type foaf:Person .
foaf:familyName "Premkumar"^^xsd:string;
foaf:givenName "Madhumita"^^xsd:string;
foaf:name "Madhumita Premkumar"^^xsd:string;
rdf:type foaf:Person .
foaf:familyName "Gupta"^^xsd:string;
foaf:givenName "Pankaj"^^xsd:string;
foaf:name "Pankaj Gupta"^^xsd:string;
rdf:type foaf:Person .
foaf:familyName "Duseja"^^xsd:string;
foaf:givenName "Ajay"^^xsd:string;
foaf:name "Ajay Duseja"^^xsd:string;
rdf:type foaf:Person .
foaf:familyName "Sharma"^^xsd:string;
foaf:givenName "Prerna"^^xsd:string;
foaf:name "Prerna Sharma"^^xsd:string;
rdf:type foaf:Person .
foaf:familyName "Mehtani"^^xsd:string;
foaf:givenName "Rohit"^^xsd:string;
foaf:name "Rohit Mehtani"^^xsd:string;
rdf:type foaf:Person .
foaf:familyName "Sandhu"^^xsd:string;
foaf:givenName "Anchal"^^xsd:string;
foaf:name "Anchal Sandhu"^^xsd:string;
rdf:type foaf:Person .
foaf:name "Gastroenterology"^^xsd:string;
rdf:type bibo:Collection .