TY  - JOUR
N1  - copyright of this article belongs to American Chemical Society (ACS)
ID  - open3394
UR  - https://pubs.acs.org/doi/10.1021/acs.joc.2c02171
IS  - 1
A1  - Sharma, Yogesh
A1  - Pawar, Ganesh P
A1  - Chaudhari, Vinod D
Y1  - 2023/01/06/
N2  - Benzothiazine 1,1-dioxide (BTDO) is a privileged chemical motif, and its metal-free domino access is in high demand. Current BTDO production methods require costly metal catalysts or harsh reaction conditions. A facile domino approach to BTDO via a water-gas shift reaction (WGSR) employing sodium 2-nitrobenzenesulfinates and ?-bromo ketones is presented. This strategy is cost-effective and environmentally beneficial. The optimized reaction conditions demonstrated remarkable chemical tolerance to a wide range of electrically and sterically varied substituents on both coupling partners.
PB  - American Chemical Society (ACS)
JF  - J. Org. Chem.
VL  - 88
TI  - One-pot domino reaction: Direct access to polysubstituted 1,4-benzothiazine 1,1-dioxide via water-gas shift reaction utilizing DMF/H2O
SP  - 701
EP  - 710
ER  -