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primary topic: Sustainable nanoparticles from Stephania glabra and analysis of their anticancer potential on 2D and 3D models of prostate cancer

Sustainable nanoparticles from Stephania glabra and analysis of their anticancer potential on 2D and 3D models of prostate cancer
type: AcademicArticle
type: Article
abstract: In pursuit of a novel effective treatment for prostate cancer, methanolic extract of Stephania glabra tubers (Sg-ME) was utilized to fabricate silver (Sg-AgNP), copper oxide (Sg-CuONP), and silver-copper bimetallic nanoparticles (Sg-BNP). The characterization of the nanoparticles confirmed spherical shape with average diameters of 30.72, 32.19, and 25.59 nm of Sg-AgNP, Sg-CuONP, and Sg-BNP, respectively. Interestingly, these nanoparticles exhibited significant cytotoxicity toward the prostate cancer (PC3) cell line while being non-toxic toward normal cells. The nanoparticles were capable of inducing apoptosis in PC3 cells by enhancing reactive oxygen species (ROS) generation and mitochondrial depolarization. Furthermore, the shrinkage of 3D prostate tumor spheroids was observed after 4 days of treatment with these green nanoparticles. The 3D model system was less susceptible to nanoparticles as compared to the 2D model system. Sg-BNP showed the highest anticancer potential on 2D and 3D prostate cancer models.
date: 2023-09-08
volume: 196
issue: 6
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
subject: QR Microbiology

Springer Science and Business Media LLC
type: Organization

Appl. Biochem. Biotechnol.
type: Collection

Deepak Sharma
type: Person
given name: Deepak
family name: Sharma

Eshu Singhal Sinha
type: Person
given name: Eshu Singhal
family name: Sinha

Raju Kumar Gupta
type: Person
given name: Raju Kumar
family name: Gupta

Prachi Vaid
type: Person
given name: Prachi
family name: Vaid

Reena V Saini
type: Person
given name: Reena V
family name: Saini

Adesh K Saini
type: Person
given name: Adesh K
family name: Saini

Vijay Kumar Thakur
type: Person
given name: Vijay Kumar
family name: Thakur

Walaa F Alsanie
type: Person
given name: Walaa F
family name: Alsanie

HTML Summary of #3409 Sustainable nanoparticles from Stephania glabra and analysis of their anticancer potential on 2D and 3D models of prostate cancer
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primary topic: Sustainable nanoparticles from Stephania glabra and analysis of their anticancer potential on 2D and 3D models of prostate cancer

QR Microbiology
type: Concept