TY  - JOUR
N1  - Copyright of this article belongs to Springer Science and Business Media LLC
ID  - open3409
UR  - https://link.springer.com/article/10.1007/s12010-023-04700-w
IS  - 6
A1  - Vaid, Prachi
A1  - Saini, Adesh K
A1  - Gupta, Raju Kumar
A1  - Sinha, Eshu Singhal
A1  - Sharma, Deepak
A1  - Alsanie, Walaa F
A1  - Thakur, Vijay Kumar
A1  - Saini, Reena V
Y1  - 2023/09/08/
N2  - In pursuit of a novel effective treatment for prostate cancer, methanolic extract of Stephania glabra tubers (Sg-ME) was utilized to fabricate silver (Sg-AgNP), copper oxide (Sg-CuONP), and silver-copper bimetallic nanoparticles (Sg-BNP). The characterization of the nanoparticles confirmed spherical shape with average diameters of 30.72, 32.19, and 25.59 nm of Sg-AgNP, Sg-CuONP, and Sg-BNP, respectively. Interestingly, these nanoparticles exhibited significant cytotoxicity toward the prostate cancer (PC3) cell line while being non-toxic toward normal cells. The nanoparticles were capable of inducing apoptosis in PC3 cells by enhancing reactive oxygen species (ROS) generation and mitochondrial depolarization. Furthermore, the shrinkage of 3D prostate tumor spheroids was observed after 4 days of treatment with these green nanoparticles. The 3D model system was less susceptible to nanoparticles as compared to the 2D model system. Sg-BNP showed the highest anticancer potential on 2D and 3D prostate cancer models.
PB  - Springer Science and Business Media LLC
JF  - Appl. Biochem. Biotechnol.
VL  - 196
KW  - Stephania glabra ; 3D tumor model; Apoptosis; Bimetallic nanoparticles; Copper oxide nanoparticles; Prostate cancer; Silver nanoparticles
TI  - Sustainable nanoparticles from Stephania glabra and analysis of their anticancer potential on 2D and 3D models of prostate cancer
SP  - 3511
EP  - 3533
ER  -