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primary topic: Candida auris: a multidimensional focus on its identification, epidemiology, pathogenesis, and therapeutic options

Candida auris: a multidimensional focus on its identification, epidemiology, pathogenesis, and therapeutic options
type: AcademicArticle
type: Article
abstract: Humans have encountered many epidemics caused by pathogenic microorganisms since the turn of the century. The prevalence of fungal infections has significantly increased on a global scale, adversely impacting human health. Candida species remain among the most prevalent and widely spread opportunistic fungi, with Candida auris emerging as a notorious hospital-acquired pathogen. This fungal pathogen causes nosocomial bloodstream infections (BSI), coupled with a high in-hospital death rate and significant multidrug-resistance (MDR). Standard quaternary ammonium compounds (Quats), are often ineffective, requiring the use of Environmental Protection Agency (EPA)-registered hospital-grade disinfectants. Routine laboratory procedures often fail to efficiently identify the fungi, making it difficult to predict the infection's true severity. Hence, molecular-based methods are now considered the gold standard for rapid identification. Despite the availability of approved drugs, their efficacy is questionable due to the emerging drug resistance within the fungal population. The organism appears to acquire drug resistance quickly. While echinocandins remain first-line therapy, the emergence of echinocandin-or pan-resistant cases indicates that treating pan-resistant strains would be particularly tricky, if not unfeasible. This underscores the urgent need for enhanced infection control, improved point-of-care diagnostics, and the development of novel therapeutic strategies. This article highlights the crucial aspects of epidemiology, identification techniques, drug resistance mechanisms, treatments, and challenges associated with C. auris infections. Understanding these interconnected aspects is essential for optimizing clinical management and mitigating the escalating public health crisis posed by this tenacious pathogen.
date: 2026-04-07
volume: 208
issue: 6
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Candida auris: a multidimensional focus on its identification, epidemiology, pathogenesis, and therapeutic options (HTML)
subject: QR Microbiology

Candida auris: a multidimensional focus on its identification, epidemiology, pathogenesis, and therapeutic options (HTML)
type: Document
has file: references (3).bib
has part: references (3).bib

SPRINGER HEIDELBERG
type: Organization

ARCHIVES OF MICROBIOLOGY
type: Collection

Milani Sharma
type: Person
given name: Milani
family name: Sharma

Nandini Verma
type: Person
given name: Nandini
family name: Verma

Kanika Multani
type: Person
given name: Kanika
family name: Multani

Praveen Rishi
type: Person
given name: Praveen
family name: Rishi

Preeti Negi
type: Person
given name: Preeti
family name: Negi

Khem Raj
type: Person
given name: Khem
family name: Raj

Seema Kumari
type: Person
given name: Seema
family name: Kumari

HTML Summary of #3451 Candida auris: a multidimensional focus on its identification, epidemiology, pathogenesis, and therapeutic options
format: text/html
primary topic: Candida auris: a multidimensional focus on its identification, epidemiology, pathogenesis, and therapeutic options

QR Microbiology
type: Concept