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primary topic: Evaluating the evolutionary relationship of TATA binding protein (TBP) with various folding patterns of protein domains using support vector machine (SVM)

Evaluating the evolutionary relationship of TATA binding protein (TBP) with various folding patterns of protein domains using support vector machine (SVM)
type: AcademicArticle
type: Article
abstract: This study focuses on the TATA-box binding, transcription initiation factor TFIID protein, (1tba) and employs a comprehensive approach combining structural, sequence and machine learning-based analysis to investigate its evolutionary relationships. By examining the TATA-box binding like protein, the study aims to identify similarities with other known protein folds, shedding light on its evolutionary relationship, and functional connections. To validate these relationships, a support vector machine (SVM) based algorithm was developed, which was complemented by another machine learning technique random forest, to ensure robust and reliable results. The integrated findings from structural, sequence, and machine learning analysis revealed several domain folds evolutionary related to TATA-box binding protein-like (1tba, B). The SVM-based method developed in this study serves as a valuable tool for identifying novel or functionally similar TATA-box binding proteins, providing deeper insights into their evolutionary and structural relationships. This work not only advances our understanding of the TATA-box binding protein family but also demonstrates the power of integrating computational and machine learning approaches in protein evolution research.
date: 2026-02-07
volume: 16
issue: 1
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Evaluating the evolutionary relationship of TATA binding protein (TBP) with various folding patterns of protein domains using support vector machine (SVM) (HTML)
subject: QR Microbiology

Evaluating the evolutionary relationship of TATA binding protein (TBP) with various folding patterns of protein domains using support vector machine (SVM) (HTML)
type: Document
has file: references (6).bib
has part: references (6).bib

NATURE PORTFOLIO
type: Organization

SCIENTIFIC REPORTS
type: Collection

Muthu Krishnan Selvaraj
type: Person
given name: Muthu Krishnan
family name: Selvaraj

Jasmeet Kaur
type: Person
given name: Jasmeet
family name: Kaur

HTML Summary of #3455 Evaluating the evolutionary relationship of TATA binding protein (TBP) with various folding patterns of protein domains using support vector machine (SVM)
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primary topic: Evaluating the evolutionary relationship of TATA binding protein (TBP) with various folding patterns of protein domains using support vector machine (SVM)

QR Microbiology
type: Concept