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primary topic: Ovarian Rev-erbα: a central regulator of fertility following chronodisruption

Ovarian Rev-erbα: a central regulator of fertility following chronodisruption
type: AcademicArticle
type: Article
abstract: Introduction Circadian rhythm disruption caused by shift work, nutritional imbalance, and the stresses of modern life can alter hormone secretion, lead to menstrual irregularities, impair follicle development, and contribute to ovarian hypoplasia. The mechanistic role of circadian rhythm disruption in reproductive disorders has been thoroughly investigated. Nuclear receptors are known to play an important role in female reproduction and in maintaining pregnancy. Rev-erb alpha, a circadian nuclear receptor, is a key component of the circadian clock and helps sustain circadian rhythm.Materials and Methods We evaluated the potential prophylactic and therapeutic functions of Rev-erb alpha in supporting female fertility by orchestrating a series of events that culminate in successful pregnancy. We generated a circadian rhythm-disrupted female mouse model to study fertility.Results The Rev-erb alpha ligand SR9011 improved the fertility index in these circadian rhythm-disrupted female mice. Moreover, SR9011 treatment restored impaired ovarian follicular cell proliferation and division, regulated steroidogenesis and steroid hormone production, enhanced progesterone and melatonin secretion, and mitigated the adverse effects of circadian disruption on folliculogenesis. SR9011 also reduced follicular atresia and promoted follicle development in CR-disrupted mice. Rev-erb alpha is a key regulator influencing oocyte retrieval, as demonstrated in mice treated with the Rev-erb alpha antagonist SR8278.Discussion/Conclusion These findings suggest that targeting Rev-erb alpha signaling and elucidating its mechanistic role in female reproduction could inform the development of more effective strategies for treating female infertility. As a sought-after druggable target, Rev-erb alpha has a broad range of potential therapeutic applications and has recently attracted considerable attention in the context of female infertility treatment.
date: 2026-02-18
volume: 17
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Ovarian Rev-erbα: a central regulator of fertility following chronodisruption (HTML)
subject: QR Microbiology

Ovarian Rev-erbα: a central regulator of fertility following chronodisruption (HTML)
type: Document
has file: references (5).bib
has part: references (5).bib

FRONTIERS MEDIA SA
type: Organization

FRONTIERS IN ENDOCRINOLOGY
type: Collection

Sumit Kumar
type: Person
given name: Sumit
family name: Kumar

Anshu Bhardwaj
type: Person
given name: Anshu
family name: Bhardwaj

Rahul Sharma
type: Person
given name: Rahul
family name: Sharma

Saumyata Kumawat
type: Person
given name: Saumyata
family name: Kumawat

Shalini Gupta
type: Person
given name: Shalini
family name: Gupta

Vipashu Kaushal
type: Person
given name: Vipashu
family name: Kaushal

Neeraj Khatri
type: Person
given name: Neeraj
family name: Khatri

Pawan Gupta
type: Person
given name: Pawan
family name: Gupta

Rashmi Arora
type: Person
given name: Rashmi
family name: Arora

HTML Summary of #3457 Ovarian Rev-erbα: a central regulator of fertility following chronodisruption
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primary topic: Ovarian Rev-erbα: a central regulator of fertility following chronodisruption

QR Microbiology
type: Concept