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primary topic: Inactivation kinetics for plasmonic photothermal based eradication of ESKAPE and Candida albicans pathogens

Inactivation kinetics for plasmonic photothermal based eradication of ESKAPE and Candida albicans pathogens
type: AcademicArticle
type: Article
abstract: Leading cause of nosocomial infections worldwide i.e., Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter species collectively referred as ESKAPE and Candida albicans that are associated with high morbidity and mortality rates, tends to develop resistance or escape conventional antimicrobial strategies. This study presents, for the first time, a detailed temperature-time kinetic analysis of the plasmonic photothermal technique against the entire spectrum of ESKAPE and C. albicans pathogens, both individually and in complex combinations thereof. Literature reports inactivation kinetics based on isothermal and non-isothermal principles which involve water baths, oil baths, or thermoresistometer, etc. to obtain the desired inactivation. Here, inactivation kinetics of combination of pathogens, ESKAPE and Candida albicans (with initial load of 5 & times; 10(7) CFU/mL of each pathogen) using plasmonic photothermal technique (broadband irradiation in the presence triangular silver nanoplates) are investigated in detail. The result showed complete eradication of the pathogens combination within similar to 10 min at 74 degrees C. Further, effective killing/inactivation of individual pathogens was achieved in merely 3-7.5 min (similar to 48 degrees C - 60 degrees C). The obtained inactivation kinetics revealed key aspects of the pathogen like major morphological changes/alterations including the presence of injured or thermotolerant populations, which were evidenced by shoulder, tailing, and sigmoidal patterns in the survival curves. However, broadband irradiation alone and triangular silver nanoplates alone provided non-significant antimicrobial effect even after 15 min of exposure duration. Further, assessment of inactivation mechanism of pathogens on plasmonic photothermal technique demonstrated reactive oxygen species (ROS) generation and cytoplasmic DNA efflux, thereby revealing synergistic ef…
date: 2026-05
volume: 278
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Inactivation kinetics for plasmonic photothermal based eradication of ESKAPE and Candida albicans pathogens (HTML)
subject: QR Microbiology

Inactivation kinetics for plasmonic photothermal based eradication of ESKAPE and Candida albicans pathogens (HTML)
type: Document
has file: references (7).bib
has part: references (7).bib

ELSEVIER SCIENCE SA
type: Organization

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
type: Collection

Sanjeev Soni
type: Person
given name: Sanjeev
family name: Soni

Sarabjot Kaur
type: Person
given name: Sarabjot
family name: Kaur

Rajneesh Dadwal
type: Person
given name: Rajneesh
family name: Dadwal

Parminder Kaur
type: Person
given name: Parminder
family name: Kaur

Hemraj Nandanwar
type: Person
given name: Hemraj
family name: Nandanwar

HTML Summary of #3460 Inactivation kinetics for plasmonic photothermal based eradication of ESKAPE and Candida albicans pathogens
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primary topic: Inactivation kinetics for plasmonic photothermal based eradication of ESKAPE and Candida albicans pathogens

QR Microbiology
type: Concept