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primary topic: Comprehensive findings of functional modulations linked to structural intricacies in DNA binding for HapR/LuxR homologues from the Vibrionaceae family

Comprehensive findings of functional modulations linked to structural intricacies in DNA binding for HapR/LuxR homologues from the Vibrionaceae family
type: AcademicArticle
type: Article
abstract: LuxR/HapR homologues play important roles in the regulation of virulence and protease genes in pathogenic Vibrio species like V. cholerae, V. vulnificus, V. parahaemolyticus, etc. as well as providing physiological advantages such as resistance to protozoan grazing, motility and chitin-induced competence in the aqueous environments. They are commonly termed as the high cell density master regulators. They are highly conserved in sequence and structure among the Vibrios and can recognize and bind to common DNA promoters, like activation of protease production in V. cholerae by SmcR of V. vulnificus. Despite this conservation, critical differences occur due to amino acid divergence in their sequences. In the present study, we compare the degree of functional conservation among HapR/LuxR homologues selected from various clades of the Vibrionaceae family, using a hapR mutant V. cholerae strain as a model organism. We also delve into the structural intricacies of distant HapR/LuxR homologues, such as LuxR proteins of Photobacterium spp. and HapR of Vibrio mimicus, a close homologue of V. cholerae. Evolutionary implications arising from sequence divergence are also recorded in the structural changes through the crystal structure analysis. The study compared several structural constraints responsible for the variation in functions related to transcriptional regulation.
date: 2026-03-05
volume: 348
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Comprehensive findings of functional modulations linked to structural intricacies in DNA binding for HapR/LuxR homologues from the Vibrionaceae family (HTML)
subject: QR Microbiology

Comprehensive findings of functional modulations linked to structural intricacies in DNA binding for HapR/LuxR homologues from the Vibrionaceae family (HTML)
type: Document
has file: references.bib
has part: references.bib

ELSEVIER
type: Organization

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
type: Collection

Angira Saha
type: Person
given name: Angira
family name: Saha

Srinivasan Krishnamurthi
type: Person
given name: Srinivasan
family name: Krishnamurthi

Saumen Datta
type: Person
given name: Saumen
family name: Datta

Himanshu Sen
type: Person
given name: Himanshu
family name: Sen

Shradha Surin
type: Person
given name: Shradha
family name: Surin

Joyasree Das
type: Person
given name: Joyasree
family name: Das

Debayan Saha
type: Person
given name: Debayan
family name: Saha

Manjula Ekka
type: Person
given name: Manjula
family name: Ekka

Saumya Raychaudhuri
type: Person
given name: Saumya
family name: Raychaudhuri

Gourab Basu Choudhury
type: Person
given name: Gourab Basu
family name: Choudhury

HTML Summary of #3463 Comprehensive findings of functional modulations linked to structural intricacies in DNA binding for HapR/LuxR homologues from the Vibrionaceae family
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primary topic: Comprehensive findings of functional modulations linked to structural intricacies in DNA binding for HapR/LuxR homologues from the Vibrionaceae family

QR Microbiology
type: Concept