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primary topic: Chronic hyperglycemia induces macrophage iron accumulation and promotes Mycobacterium tuberculosis virulence

Chronic hyperglycemia induces macrophage iron accumulation and promotes Mycobacterium tuberculosis virulence
type: AcademicArticle
type: Article
abstract: Tuberculosis-diabetes comorbidity represents significant global health challenges, though the underlying mechanisms remain poorly understood. Mycobacterium tuberculosis (M.tb), the causative agent of tuberculosis, has a very high requirement of iron and its availability is a determining factor for successful establishment of infection. Host innate immune system and macrophages attempt to limit iron availability to restrict bacterial growth. We investigated the relationship between hyperglycemia and intracellular iron dynamics during infection using, THP-1-derived and primary macrophages from diabetic mice maintained under high-glucose conditions. Both showed increased intracellular iron along with higher expression of iron uptake receptors. Bacteria inside macrophages also contained more iron. Iron chelation significantly reduced M.tb burden in the lungs and spleen of infected diabetic mice. These findings suggest that hyperglycemia creates a ``glucose legacy'' that promotes iron accumulation, thereby increasing host susceptibility to M.tb infection, and reveals iron chelation as a promising adjunct therapeutic strategy.
date: 2026-06-05
volume: 29
issue: 6
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Chronic hyperglycemia induces macrophage iron accumulation and promotes Mycobacterium tuberculosis virulence (HTML)
subject: QR Microbiology

Chronic hyperglycemia induces macrophage iron accumulation and promotes Mycobacterium tuberculosis virulence (HTML)
type: Document
has file: references (8).bib
has part: references (8).bib

Elsevier BV
type: Organization

iScience
type: Collection

Surbhi Chaudhary
type: Person
given name: Surbhi
family name: Chaudhary

Chaaya Iyengar Raje
type: Person
given name: Chaaya Iyengar
family name: Raje

Rahul Dilawari
type: Person
given name: Rahul
family name: Dilawari

Ajay Kumar
type: Person
given name: Ajay
family name: Kumar

Anurag Sindhu
type: Person
given name: Anurag
family name: Sindhu

Asmita Dhiman
type: Person
given name: Asmita
family name: Dhiman

Manoj Raje
type: Person
given name: Manoj
family name: Raje

Sharmila Talukdar
type: Person
given name: Sharmila
family name: Talukdar

Anil Patidar
type: Person
given name: Anil
family name: Patidar

Radheshyam Modanwal
type: Person
given name: Radheshyam
family name: Modanwal

Gaurav Kumar Chaubey
type: Person
given name: Gaurav Kumar
family name: Chaubey

HTML Summary of #3479 Chronic hyperglycemia induces macrophage iron accumulation and promotes Mycobacterium tuberculosis virulence
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primary topic: Chronic hyperglycemia induces macrophage iron accumulation and promotes Mycobacterium tuberculosis virulence

QR Microbiology
type: Concept