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primary topic: Association of Mycobacterium avium paratuberculosis With Crohn's Disease: A Large Multicenter Study From a Tuberculosis-Endemic Region

Association of Mycobacterium avium paratuberculosis With Crohn's Disease: A Large Multicenter Study From a Tuberculosis-Endemic Region
type: AcademicArticle
type: Article
abstract: BackgroundThe causal relationship between Crohn's disease (CD) and Mycobacterium avium subspecies paratuberculosis (MAP) remains controversial.MethodsThis multicenter observational study was conducted across seven tertiary care centers in India enrolled newly diagnosed, treatment-na\"\ive Crohn's disease (CD) patients as cases, and treatment-na\"\ive intestinal tuberculosis (ITB), ulcerative colitis (UC), and healthy individuals undergoing sigmoidoscopy for hemorrhoids as controls. Mycobacterium avium subspecies paratuberculosis (MAP) detection was performed using serology for MAP antibodies, PCR, RT-qPCR, and solid/liquid cultures on blood and colonic biopsies. In situ PCR and immunohistochemistry (IHC) were additionally applied to paraffin-embedded tissue sections to evaluate MAP presence across groups.FindingsA total of 889 participants were recruited (CD=148, ITB=288, UC=251 and non-IBD controls=202) were included. The seropositivity of MAP was significantly higher in patients with CD compared to controls (20.6% 13/63 vs healthy controls: 16.2\% 12/74; ITB: 7.8\% 9/116; UC: 4.8\% 4/84; pInterpretationFindings of our study suggest an increased association of MAP and CD. Future studies should explore possible causal role of MAP in CD and potential therapeutic options to target MAP.
date: 2026-05-20
volume: 82
issue: 5
status: peerReviewed
status: published
author list: authors
type: EPrint
type: ArticleEPrint
is part of: repository
has document: Association of Mycobacterium avium paratuberculosis With Crohn's Disease: A Large Multicenter Study From a Tuberculosis-Endemic Region (HTML)
subject: QR Microbiology

Association of Mycobacterium avium paratuberculosis With Crohn's Disease: A Large Multicenter Study From a Tuberculosis-Endemic Region (HTML)
type: Document
has file: references (2).bib
has part: references (2).bib

Oxford University Press (OUP)
type: Organization

Clin. Infect. Dis.
type: Collection

Vineet Ahuja
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family name: Ahuja

Shobna Bhatia
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given name: Shobna
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Sudheer Kumar Vuyyuru
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given name: Sudheer Kumar
family name: Vuyyuru

Siddhartha Dattagupta
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given name: Siddhartha
family name: Dattagupta

Kannan Palaniyandi
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given name: Kannan
family name: Palaniyandi

Rakesh Kochhar
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given name: Rakesh
family name: Kochhar

Saroj Kant Sinha
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given name: Saroj Kant
family name: Sinha

Kusum Sharma
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family name: Sharma

Rupesh Pokharna
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Shiv Basant
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Sreenivas Vishnubhatla
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given name: Sreenivas
family name: Vishnubhatla

Gopal Krishna Dhali
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given name: Gopal Krishna
family name: Dhali

B S Ramakrishnan
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given name: B S
family name: Ramakrishnan

Charu Sharma
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given name: Charu
family name: Sharma

Prasenjit Das
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given name: Prasenjit
family name: Das

Rajib Sarkar
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Urvashi Singh
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Manjula Singh
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Vishwajeet Singh
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Bharti Malhotra
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given name: Bharti
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HTML Summary of #3489 Association of Mycobacterium avium paratuberculosis With Crohn's Disease: A Large Multicenter Study From a Tuberculosis-Endemic Region
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primary topic: Association of Mycobacterium avium paratuberculosis With Crohn's Disease: A Large Multicenter Study From a Tuberculosis-Endemic Region

QR Microbiology
type: Concept